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Volume 14, Number 4—April 2008

Dispatch

Single Nucleotide Polymorphism Typing of Bacillus anthracis from Sverdlovsk Tissue

Richard T. Okinaka*†, Melinda Henrie*, Karen K. Hill*, KristinS. Lowery‡, Matthew Van Ert†, Talima Pearson†, James Schupp†, Leo Kenefic†, Jodi Beaudry†, Steven A. Hofstadler‡, Paul J. Jackson*§, and Paul Keim*†¶Comments to Author 
Author affiliations: *Los Alamos National Laboratory, Los Alamos, New Mexico, USA; †Northern Arizona University, Flagstaff, Arizona, USA; ‡Ibis Biosciences Inc, Carlsbad, California, USA; §Lawrence Livermore National Laboratory, Livermore, California, USA; ¶Translational Genomics Research Institute, Phoenix, Arizona, USA;

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Table

Canonical single nucleotide polymorphism (canSNP) typing and a new pagA SNP from Sverdlovsk 7.RA93.15.15 (spleen)*
View Actual Table

Isolate Country of origin Lineage/group (10) canSNP,
A.Br.007 canSNP,
A.Br.008 canSNP,
A.Br.009 SNP,
pagA 981
A1055 C.Br.A055 T T A –pXO1
KrugerB B.Br.KrugerB T T A A
CNEVA.9066 B.Br.CNEVA T T A A
Ames A.Br.Ames T T A A
Sterne A.Br.Ames T T A A
Australia94 A.Br.Aust94 T T A A
Vollum A.Br.Vollum C T A A
(Branch point) A.Br.008/009 T G A
Sv7,RA93.15.15 (spleen) A.Br.008/009 T G A T
Sv31.RA93.39.3 T
Sv40.RA93.40.5 T
Sv25.RA93.031 T
Sv1.RA93.42.1 T
Sv33.RA93.20.5 T
Sv21.RA93.38.4 T
Western North America A.Br.WNA T G G A
A0362 Norway A.Br.008/009 T G A T
A0417 Hungary A.Br.008/009 T G A T
A0324 Slovakia A.Br.008/009 T G A T
A0293 Italy A.Br.008/009 T G A A
A0463 Pakistan A.Br.008/009 T G A A
A0149 Turkey A.Br.008/009 T G A A
A0264 Turkey A.Br.008/009 T G A A
A0032 China A.Br.008/009 T G A A
A0033 China A.Br.008/009 T G A A
A0241 Turkey A.Br.008/009 T G A A
A0245 Turkey A.Br.008/009 T G A A
A0463 Pakistan A.Br.008/009 T G A A

*This table illustrates 2 canSNPs that distinguish the subgroup/branch point A.Br.008/009 from the Western North American (WNA) sublineage. The table also depicts the status of the pagA 981 SNP in 7 of 12 Sverdlovsk samples and several other key isolates. Black shading, WNA lineage; gray shading, subgroup A.Br.008/009.

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