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Volume 14, Number 4—April 2008

Research

Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France

Marie Desnos-Ollivier*, Stéphane Bretagne*†, Claire Bernède*‡, Vincent Robert§, Dorothée Raoux*, Elisabeth Chachaty¶, Elisabeth Forget#, Claire Lacroix**, Françoise Dromer*Comments to Author , and the YEASTS group
Author affiliations: *Institut Pasteur, Paris, France; †Hôpital Henri Mondor–Assistance Publique Hôpitaux de Paris, Créteil, France; ‡Institut Pasteur Institut National de la Santé et de la Recherche Médicale Unité 657, Paris, France; §Centraal Bureau voor Schimmelcultures, Utrecht, the Netherlands; ¶Institut Gustave-Roussy, Villejuif, France; #Hôpital Beaujon, Clichy, France; **Hôpital Saint Louis, Paris, France;

Main Article

Table 4

Patient characteristics according to the 3 categories delineated by the susceptibility of the Candida tropicalis isolates to flucytosine (5FC) and their belonging to the R5FC clone*

Characteristic S5FC (n = 85) R5FC clone (n = 29) Other R5FC (n = 16) p value†
>60 y of age 39 (46) 17 (59) 9 (56) 0.452
Male 55 (65) 18 (62) 10 (63) 0.962
Had malignancies 41 (48) 22 (76) 9 (56) 0.033
Cancerous 15 (18) 7 (24) 5 (31) 0.374
Hematologic 26 (31) 15 (52) 4 (25) 0.082
In intensive care unit 44 (52) 12 (41) 4 (25) 0.116
Had central venous catheter 68 (80) 24 (83) 12 (75) 0.894
Had recent surgery 27 (32) 8 (30) 4 (25) 0.918
Had prior antifungal therapy 11 (13) 0 2 (13) 0.093
Died before day 30 34/81 (42) 6/28 (21) 10/15 (67) 0.014

*S subscript, susceptible; R subscript, resistant. Values are no. (%).
†Fisher exact test.

Main Article

1The YEASTS group is composed of (in alphabetical order by city): Claire Bouges-Michel (Hôpital Avicenne, Bobigny), Isabelle Poilane (Hôpital Jean Verdier, Bondy), Marie-Elisabeth Bougnoux, Jean Dunand (Hôpital Ambroise Paré, Boulogne), Guy Galeazzi (Hôpital Louis Mourier, Colombes), Stéphane Bretagne, Françoise Botterel (Hôpital Henri Mondor, Créteil), Nathalie Fauchet (Centre Hospitalier Intercommunal de Créteil, Créteil), Elisabeth Forget (Hôpital Beaujon, Clichy), Françoise Botterel, Christine Bonnal (Hôpital du Kremlin Bicêtre), Odile Eloy (Hôpital Mignot, Le Chesnay), Christine Lawrence (Hôpital Raymond Poincaré, Garches), Marie-Françoise David, Liliana Mihaila (Hôpital Paul Brousse, Villejuif), Elisabeth Chachaty, Olivier Adam (Institut Gustave Roussy, Villejuif), and in Paris: Christian Chochillon (Hôpital Bichat), André Paugam, Marie-Thérèse Baixench (Hôpital Cochin), Muriel Cornet (Hôpital de l’Hôtel Dieu), Marie-Christine Escande (Institut Curie), Svetlana Challier, Marie-Elisabeth Bougnoux (Hôpital Necker), Eric Dannaoui (Hôpital Européen Georges Pompidou), Annick Datry, Houria Laklache, Bader Lmimouni, Sophie Brun (Hôpital de la Pitié-Salpétrière), Jean-Louis Poirot (Hôpital Saint Antoine), Claire Lacroix (Hôpital Saint Louis), Didier Moissenet (Hôpital Trousseau), Michel Develoux (Hôpital Tenon), and Stéphane Bonacorsi (Hôpital Robert Debré).

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