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Volume 14, Number 4—April 2008

Research

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Boris Klempa*†2, Evgeniy A. Tkachenko‡2, Tamara K. Dzagurova‡, Yulia V. Yunicheva‡, Vyacheslav G. Morozov‡, Natalia M. Okulova‡, Galina P. Slyusareva‡, Aleksey Smirnov‡, and Detlev H. Kruger*Comments to Author 

Author affiliations: *Charité School of Medicine, Berlin, Germany; †Slovak Academy of Sciences, Bratislava, Slovakia; ‡Russian Academy of Medical Sciences, Moscow, Russia;

Main Article

Table 5

Results of typing of neutralizing antibodies in serum from patients with Dobrava-Belgrade virus–associated hemorrhagic fever with renal syndrome, Russia

Region Sample no. Time after onset of disease FRNT titer* against
Sochi/Ap Lipetsk/Aa Slo/Af SK/Aa HTNV SEOV PUUV
Sochi (2000–2006)
1,312 104 d 2,560 80 160 ND 160 <80 <40
3,692 30 d 1,280 160 160 ND <80 <80 <40
1,291 16 d 640 160 160 ND 40 40 <40
4,714 1 y, 5 mo >20,480 5,120 5,120 ND 320 320 <40
1,310 50 d 2,560 640 640 ND 160 160 <40
1,307 15 d 640 320 320 ND 160 160 <40
4,716 5 y, 3 mo 5,120 1,280 2,560 ND 160 <80 <40
4,715
1 y, 4 mo
5,120
2,560
5,120
ND
ND
ND
<40
Lipetsk (2001–2002)
4,338 6 mo 160 640 160 320 ND† ND† ND†
3,894 21 d 40 640 40 160 ND† ND† ND†
4,334 3 y, 6 mo 160 640 320 160 ND† ND† ND†
4,344 6 mo 160 640 320 640 ND† ND† ND†
3,958 3 mo 20 80 80 40 ND† ND† ND†
4,329
3 y, 4 mo
640
640
2,560
640
ND†
ND†
ND†
Slovakia B38 3 y, 9 mo 2,560 640 5,120 2,560 40 640 40
B39 3 y, 9 mo 2,560 1,280 10,240 2,560 160 160 40

*FRNT, focus-reduction neutralization test. Reciprocal end-point titers are given as determined by chemiluminescence FRNT. ND, not determined.
†Serum previously characterized as anti–Dobrava-Belgrade virus (DOBV) in a first FRNT investigation with Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), and DOBV–Slo/Af only.

Main Article

1This work is dedicated to the memory of our friend and colleague Milan Labuda, who died in August 2007.

2These authors contributed equally to this article.

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