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Volume 14, Number 6—June 2008

Dispatch

Nosocomial Outbreaks Caused by Leuconostoc mesenteroides subsp. mesenteroides

Germán Bou*Comments to Author , Jesús Luis Saleta*, Juan Antonio Sáez Nieto†, Mar Tomás*, Silvia Valdezate†, Dolores Sousa*, Francisco Lueiro*, Rosa Villanueva*, Maria Jose Pereira*, and Pedro Llinares*
Author affiliations: *Complejo Hospitalario Universitario Juan Canalejo, La Coruña, Spain; †Centro Nacional de Microbiología, Majadahonda, Madrid, Spain;

Main Article

Table 2

Model for predicting infection by L. mesenteroides subsp. mesenteroides (LM), 2003–2004, La Coruña, Spain*

Variable Cases, n = 42
Controls, n = 61
Crude OR† 
(95% CI) Adjusted OR (95% CI) p value
No. (%) Mean (SD) No. (%) Mean (SD)
Age, y 34.3 (28.2) 44.4 (31.7) 0.99 (0.98–1.0)
Time between admission and infection 33.5 (38.4) 37.5 (100.9) 0.999 (0.994–1.0) NS
Charlson score

2.94 (2.13)


4.28 (2.38)
0.76 (0.61–0.96)
NS

Previous surgery 29 (69) 23 (37.7) 3.7 (1.6–8.5) NS
Previous infections 31 (73.8) 15 (24.6) 8.6 (3.5–21.3) 4.2 (1.2–14.7) 0.023
Previous antimicrobial drug therapy 37 (88.1) 42 (68.9) 3.3 (1.1–9.9) NS
Teicoplanin 12 (28.6) 4 (6.6) 5.7 (1.7–19.2) NS
Vancomycin 5 (11.9) 3 (4.9) 2.6 (0.6–11.6)
Central venous lines
39 (92.9)


41 (67.2)

6.3 (1.7–23.0)
NS

Sex
Male
24 (57.1)


41 (67.2)

0.7 (0.3–15)


Urinary catheter 28 (66.7) 21 (34.4) 3.7 (1.6–8.6) NS
Enteral nutrition 18 (42.9) 23 (37.7) 1.2 (0.6–2.8)
Parenteral nutrition 40 (95.2) 26 (42.6) 26.9 (6–121.6) 27.8 (5.5–141.1) <0.000
Blood transfusion 24 (57.1) 31 (50.8) 1.3 (0.6–2.8)
Intubation 18 (42.9) 17 (27.9) 1.9 (0.8–4.4)
Tracheostomy 4 (9.5) 3 (4.9) 2.0 (0.4–9.6)
Treatment with steroids 8 (19) 12 (19.7) 1 (0.4–2.6)
Alteration of gastrointestinal barrier‡ 29 (69) 30 (49.2) 2.3 (1.0–5.3) NS

*Values for 42 case patients and 61 control patients. SD, standard deviation; OR, odds ratio; CI, confidence interval; NS, variable did not meet criterion for remaining in the multivariate model. All these variables were considered as potential risk factors for LM infection. The LM infection was considered as an outcome variable.
†Predictor variables with p<0.10 in univariate analysis were included in the multivariate model to enable simultaneous adjustment.
‡Any process that modifies the gastrointestinal barrier (inflammation, atresia, resection, obstruction).

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