TY - JOUR AU - Dubberke, Erik R. AU - Butler, Anne M. AU - Reske, Kimberly A. AU - Agniel, Denis AU - Olsen, Margaret A. AU - D’Angelo, Gina AU - McDonald, L. Clifford AU - Fraser, Victoria J. T1 - Attributable Outcomes of Endemic Clostridium difficile–associated Disease in Nonsurgical Patients T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 7 SP - 1031 SN - 1080-6059 AB - Data are limited on the attributable outcomes of Clostridium difficile–associated disease (CDAD), particularly in CDAD-endemic settings. We conducted a retrospective cohort study of nonsurgical inpatients admitted for >48 hours in 2003 (N = 18,050). The adjusted hazard ratios for readmission (hazard ratio 2.19, 95% confidence interval [CI] 1.87–2.55) and deaths within 180 days (hazard ratio 1.23, 95% CI 1.03–1.46) were significantly different among CDAD case-patients and noncase patients. In a propensity score matched-pairs analysis that used a nested subset of the cohort (N = 706), attributable length of stay attributable to CDAD was 2.8 days, attributable readmission at 180 days was 19.3%, and attributable death at 180 days was 5.7%. CDAD patients were significantly more likely than controls to be discharged to a long-term-care facility or outside hospital. Even in a nonoutbreak setting, CDAD had a statistically significant negative impact on patient illness and death, and the impact of CDAD persisted beyond hospital discharge. KW - Clostridium difficile KW - attributable mortality KW - outcomes KW - healthcare epidemiology KW - hospital-associated infections KW - research KW - United States DO - 10.3201/eid1407.070867 UR - https://wwwnc.cdc.gov/eid/article/14/7/07-0867_article ER - End of Reference