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Volume 14, Number 7—July 2008

Dispatch

Persistence of Diphtheria, Hyderabad, India, 2003–2006

Sailaja Bitragunta*, Manoj V. Murhekar*, Yvan J. Hutin*, Padmanabha P. Penumur†, and Mohan D. Gupte*Comments to Author 
Author affiliations: *National Institute of Epidemiology, Chennai, India; †Fever Hospital, Hyderabad, India;

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Table 2

Number of doses of diphtheria vaccine received by diphtheria case-patients and matched controls, Hyderabad, India, 2006*

No. doses received Case-patients
Controls
Odds ratio estimate Vaccine efficacy estimate, % (95% CI)
<5 y of age >5 y of age Total <5 y of age >5 y of age Total
0 6 20 26 2 11 13 Reference Reference
1 0 7 7 1 2 3 1.4 (0.22–8.9) 0 (0–78)
2 2 6 8 0 2 2 2.1 (0.37–12) 0 (0–63)
3 6 34 40 8 26 34 0.51 (0.20–1.3) 49 (0–80)
4† 7 27 34 10 30 40 0.35 (0.13–92) 65 (8–87)
5‡ NA 8 8 NA 31 31 0.09 (0.02–0.33) 91§ (68–98)

*Conditional logistic regression taking into account vaccine doses, religion, family income, and parental literacy. CI, confidence interval; NA, not applicable.
†Booster at 18 mo of age.
‡Booster at 5 y of age.
§Vaccine efficacy among children >5 y of age; younger children could not have received that booster.

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