Emerging Infectious Disease ISSN: 1080-6059

Nosocomial Outbreak of Novel Arenavirus Infection, Southern Africa

Janusz T. Paweska, Nivesh H. Sewlall, Thomas G. Ksiazek, Lucille H. Blumberg, Martin J. Hale, W. Ian Lipkin, Jacqueline Weyer, Stuart T. Nichol, Pierre E. Rollin, Laura K. McMullan, Christopher D. Paddock, Thomas Briese, Joy Mnyaluza, Thu-Ha Dinh, Victor Mukonka, Pamela Ching, Adriano Duse, Guy Richards, Gillian de Jong, Cheryl Cohen, Bridget Ikalafeng, Charles Mugero, Chika Asomugha, Mirriam M. Malotle, Dorothy M. Nteo, Eunice Misiani, Robert Swanepoel

, Sherif R. Zaki, Investigation Teams¹, and members of the Outbreak Control

Author affiliations: National Institute for Communicable Diseases, Sandringham, South Africa (J.T. Paweska, L.H. Blumberg, J. Weyer, G de Jong, C. Cohen, R. Swanepoel); University of the Witwatersrand, Johannesburg, South Africa (N.H. Sewlall, M.J. Hale, A. Duse); Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA (T.G. Ksiazek, S.T. Nichol, P.E. Rollin, L.K. McMullan, C.D. Paddock, T.-H. Dinh, S.R. Zaki); Columbia University, New York, New York, USA (W.I. Lipkin, T. Briese); Gauteng Department of Health, Johannesburg (J. Mnyaluza, B. Ikalafeng, C. Asomugha); CDC Global AIDS Program, Pretoria, South Africa (T.-H. Dinh); Ministry of Health, Lusaka, Zambia (V. Mukonka); CDC Global AIDS Program, Lusaka (P. Ching); Charlotte Maxeke Hospital, Johannesburg (G. Richards); National Department of Health, Pretoria (C. Mugero, E. Misiani); Field Epidemiology and Laboratory Training Programme, Johannesburg (M.M. Malotle, D.M. Nteo); University of Texas Medical Branch, Galveston, Texas, USA (T.G. Ksiasek)

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Figure 2

Liver biopsy specimen from patient 2 showing focal hepatocyte necrosis (arrows) without prominent inflammatory cell infiltrates (A) and Lujo virus antigens (red) distributed predominantly in a membranous pattern around infected hepatocytes (B). Hematoxylin and eosin staining in panel A and immunoalkaline phosphatase staining with naphthol fast-red stain and monoclonal antibody against GP2 Lassa virus diluted 1:1,000 in panel B. Original magnifications ×50 (A) and ×100 (B).

Figure 2. Liver biopsy specimen from patient 2 showing focal hepatocyte necrosis (arrows) without prominent inflammatory cell infiltrates (A) and Lujo virus antigens (red) distributed predominantly in a membranous pattern around infected hepatocytes (B). Hematoxylin and eosin staining in panel A and immunoalkaline phosphatase staining with naphthol fast-red stain and monoclonal antibody against GP2 Lassa virus diluted 1:1,000 in panel B. Original magnifications ×50 (A) and ×100 (B).

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¹Members of the Outbreak Control and Investigation Teams: F. Abrahams, T. Aseko, F.G. Benson, M. Bush, D. Cannon, A. Cengimbo, G. Chetty, L. Chibesakunda, C. Chisembele, J.A. Comer, A. Craig, C. De Meyer, J. Erasmus, S.M. Dickerson, E. Farnon, A.A. Grobbelaar, A. Hayward, M. Hoohlo, P. Jansen van Vuren, A. Kemp, G. Kocher, J. Koethe, P.A. Leman, W. Lubinda, R. Lynen, C. Malibata, A. Marumo, B. Matapo, T.J. Meade, D. Miller, M. Monze, V.C. Mtonga, P. Mwaba, A. Mweene, M. Naidu, T. Nemungadi, C. Oranmore-Brown, C.S. Pak, R.M. Phillips, W. Ramakrishna, Z. Reed, S. Ri, G. Richards, K. Robinson, C. Smith, G. Sharp, G.B. Song, L. van der Walt, C. Villar, L. Wamunyima.

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