TY - JOUR AU - Jones, Michael AU - Wight, Darren AU - Barron, Rona AU - Jeffrey, Martin AU - Manson, Jean AU - Prowse, Christopher AU - Ironside, James W. AU - Head, Mark W. T1 - Molecular Model of Prion Transmission to Humans T2 - Emerging Infectious Disease journal PY - 2009 VL - 15 IS - 12 SP - 2013 SN - 1080-6059 AB - To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility. KW - Transmissible spongiform encephalopathy KW - disease transmission KW - model system KW - prions KW - amino acid sequence KW - conformation KW - molecular characteristics KW - protein misfolding cyclic amplification KW - dispatch DO - 10.3201/eid1512.090194 UR - https://wwwnc.cdc.gov/eid/article/15/12/09-0194_article ER - End of Reference