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Volume 15, Number 12—December 2009

Letter

Parachlamydia and Rhabdochlamydia in Premature Neonates

Frédéric Lamoth, Sébastien Aeby, Antoine Schneider, Katia Jaton-Ogay, Bernard Vaudaux, and Gilbert GreubComments to Author 
Author affiliations: University Hospital and University of Lausanne, Lausanne, Switzerland

Main Article

Table

Characteristics of 29 newborns with positive PCR results for Parachlamydia acanthamoebae or Rhabdochlamydia spp. and controls*

Characteristics Positive PCR result, n = 12 Negative PCR result, n = 17 p value†
Sex, M/F 8 (67)/4 (33) 6 (35)/11 (65) 0.14
Gestational age at birth, wk, median (range) 27 (24–36) 30 (25–41) 0.16
Weight <10th percentile 4 (33) 4 (24) 0.68
Height <10th percentile
3 (25)
6 (35)
0.69
Primary adaptation
First Apgar score (1 min), median (range) 2.5 (0–7) 8 (2–9) 0.0017
First 3 Apgar scores,‡ median (range) 18.5 (8–27) 27 (17–29) 0.0023
Cardiac massage in first 48 h 6 (50) 0 (0) 0.002
Endotracheal intubation in first 48 h
11 (92)
8 (47)
0.019
Respiratory distress syndrome 11 (92) 14 (82) 0.62
Hyaline membranes disease 9 (75) 8 (47) 0.25
Bradypneic syndrome 7 (58) 11 (65) 1.00
Bronchopulmonary dysplasia 8 (67) 9 (53) 0.70
Amniotic fluid aspiration 1 (8) 3 (18) 0.62
Invasive mechanical ventilation, d, median (range) 12 (2–50) 3 (0–14) 0.005
Endotracheal intubation during hospital stay
12 (100)
11 (65)
0.028
Infectious complications
Lung infection 5 (42) 7 (41) 1.00
Other systemic infection
7 (58)
5 (29)
0.15
Other complications
Intraventricular hemorrhage 4 (33) 6 (35) 1.00
Persistent artery canal 7 (58) 6 (35) 0.27
Necrotizing enterocolitis 2 (17) 1 (6) 0.55
Congenital malformations
1 (8)
1 (6)
1.00
Hospitalization
Stay in neonatology ward, d,§ median (range) 113.5 (9–435) 48 (7–131) 0.003
Death
3 (25)
0 (0)
0.06
Pregnancy
Premature membranes rupture 5 (42) 6 (35) 1.00
Placental detachment 2 (17) 1 (6) 0.55
Preeclampsia 4 (33) 2 (12) 0.20
Systemic infection 7 (58) 9 (53) 1.00
Cesarean delivery 9 (75) 10 (59) 0.45

*Results are given as no. (%) except as indicated.
†Fisher exact test and nonparametric Mann-Whitney rank sum test were used for the analysis of proportions and continuous variables, respectively.
‡Sum of the 3 scores at 1, 5, and 10 min after birth.
§If survived.

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