Figure 7. Schematic genomic organization of Michigan rabbit calicivirus consistent with a Lagovirus in the family Caliciviridae. Lagoviruses contain an initial large open reading frame (ORF), ORF-1 encoding a polypeptide that overlaps with a smaller ORF, ORF-2. Numbering indicates the corresponding amino acid codons predicated from the genomic sequence. hel, helicase; Vpg, virion protein, linked to genome; pro, protease; pol, polymerase; capsid (VP60), capsid protein VP60.