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Volume 15, Number 12—December 2009

Another Dimension

A Groundhog, a Novel Bartonella Sequence, and My Father’s Death

Edward B. BreitschwerdtComments to Author , Ricardo G. Maggi, Maria Belen Cadenas, and Pedro Paulo Vissotto de Paiva Diniz
Author affiliations: North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA

Main Article

Table

PCR, blood, and CSF Bartonella spp. culture and serologic results from an 86-year-old man with recent onset arthritis, memory loss, and encephalopathy*

Date Location and sample type Serologic results (titers)
BAPGM enrichment platform
B. henselae B. vinsonii subsp. berkhoffii Direct extraction Pre-enrichment 
culture Bartonella isolate
2005 Sep 23
Home/blood
NA
NA

Neg
Neg
NIO
2006 Aug 19
Home/blood
NA
NA

Neg
Neg
NIO
2008 Jan 11 Hospital 2/blood NA NA B. volans–like Neg NIO

Hospital 2/CSF
NT
NT

B. henselae
Neg
NIO
2008 Jan 28 Hospital 2/EDTA blood 16 16 Neg Neg Bvb II

Hospital 2/ACD blood
NA
NA

Neg
Neg
Bvb II
2008 Feb 10
Home/blood
<16
128

Neg
Neg
NIO
2008 Mar 11
Hospital 3/blood
<16
64

Neg
Neg
NIO
2008 Apr 4
Hospital 3/blood
<16
32

B. volans–like
Neg
Neg
2008 Apr 28 Home/blood 16 64 Neg Bvb II Neg

*CSF, cerebrospinal fluid; BAPGM, Bartonella α Proteobacteria growth medium; NA, no available serum; Neg, DNA was not amplified by using Bartonella 16S–23S intergenic spacer primers; NIO, no isolate obtained by subculture after BAPGM pre-enrichment culture; Hospital 2, second hospitalization; NT, not tested; ACD, acid-citrate-dextrose; BvbII, B. vinsonii subsp. berkhoffii genotype II; Hospital 3, third hospitalization.

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