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Volume 15, Number 2—February 2009

Dispatch

Genomic Characterization of Novel Human Parechovirus Type

Linlin Li, Joseph Victoria, Amit Kapoor, Asif Naeem, Shahzad Shaukat, Salmaan Sharif, Muhammad Masroor Alam, Mehar Angez, Sohail Zahoor Zaidi, and Eric DelwartComments to Author 
Author affiliations: Blood Systems Research Institute, San Francisco, California, USA (L. Li, J. Victoria, A. Kapoor, E. Delwart); University of California, San Francisco (L. Li, J. Victoria, A. Kapoor, E. Delwart); National Institute of Health, Islamabad, Pakistan (A. Naeem, S. Shaukat, S. Sharif, M.M. Alam, M. Angez, S.Z. Zaidi)

Main Article

Table 1

Nucleotide and amino acid sequence comparisons of HPeV7 candidate prototype PAK5045 with the HPeV prototypes*

Sequence % Nucleotide (amino acid) identity
HPeV1 HPeV2 HPeV3 HPeV4 HPeV5 HPeV6
5′ UTR 87.6 86.8 95.9 90.2 86.7 89.8
VP0 71.0 (76.8) 69.6 (75.8) 68.3 (72.3) 69.7 (75.1) 70.1 (75.4) 69.7 (73.7)
VP3 69.5 (75.3) 69.9 (74.1) 73.2 (83.9) 70.3 (77.5) 69.7 (74.0) 68.8 (74.0)
VP1 65.8 (69.9) 66.6 (69.5) 68.9 (77.0) 67.8 (68.6) 64.7 (66.4) 63.9 (65.0)
2A 77.9 (89.3) 75.2 (84.6) 77.5 (85.9) 80.8 (89.3) 80.5 (89.9) 76.5 (85.9)
2B 80.1 (95.9) 76.8 (95.1) 86.1 (99.2) 83.6 (99.2) 83.6 (97.5) 78.7 (96.7)
2C 78.9 (91.5) 76.5 (86.6) 83.8 (96.0) 85.9 (97.0) 80.9 (94.5) 79.5 (90.0)
3A 76.6 (88.0) 76.1 (83.8) 81.8 (94.0) 87.5 (96.6) 78.9 (82.9) 76.1 (89.7)
3B 73.3 (90.0) 75.0 (90.0) 76.7 (85.0) 85.0 (95.0) 76.7 (90.0) 70.0 (90.0)
3C 81.3 (98.0) 81.2 (98.0) 83.5 (98.0) 86.3 (98.0) 80.3 (99.0) 83.0 (99.0)
3D 83.2 (94.9) 82.8 (94.0) 88.7 (96.8) 90.8 (97.2) 83.8 (95.9) 83.6 (95.3)
3′ UTR 85.1 89.8 95.5 94.4 85.2 83.0
ORF 76.3 (86.7) 75.6 (84.8) 79.5 (89.1) 80.8 (88.5) 77.0 (86.6) 76.0 (85.4)

*Sequences for the HPeV prototypes, HPeV1 (Harris, S45208), HPeV2 (Williamson, AJ005695), HPeV3 (A308/99, AB084913), HPeV4 (K251176-02, DQ315670), HPeV5 (CT86-6760, AF055846), and HPeV6 (NII561–2000, AB252582), were obtained from GenBank. HPeV, human parechoviruses.

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