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Volume 15, Number 2—February 2009

Research

Medical Procedures and Risk for Sporadic Creutzfeldt-Jakob Disease, Japan, 1999–2008

Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Yosikazu Nakamura, Takeshi Sato, Tetsuyuki Kitamoto, Hidehiro Mizusawa, and Masahito YamadaComments to Author 
Author affiliations: Kanazawa University Graduate School of Medical Science, Kanazawa, Japan (T. Hamaguchi, M. Noguchi-Shinohara, I. Nozaki, M. Yamada); Jichi Medical University, Shimotsuke, Japan (Y. Nakamura); Kohnodai Hospital, Ichikawa, Japan (T. Sato); Tohoku University Graduate School of Medicine, Sendai, Japan (T. Kitamoto); Tokyo Medical and Dental University, Tokyo, Japan (H. Mizusawa); Creutzfeldt-Jakob Disease Surveillance Committee, Japan (Y. Nakamura, T. Sato, J. Mizusawa, T. Kitamoto, M. Yamada)

Main Article

Table 4

Medical procedures and risk for sCJD, by age at disease onset, Japan, 1999–2008*

Age range, y Data category Total no. patients Any surgery Neurosurgery Ophthalmic surgery Other surgery Blood transfusion
31–50
sCJD 32 50.0% 6.3% 6.3% 40.6% 3.1%
Control 37 45.9% 10.8% 2.7% 37.8% 5.4%
OR 1.66 0.38 2.15 0.78 0.64
95% CI 0.04–74.09 0.02–6.64 0.05–101.51 0.02 – 33.39 0.05–9.09
p value

0.79
0.50
0.70
0.90
0.74
51–70
sCJD 414 43.7% 1.7% 2.2% 41.8% 9.4%
Control 97 46.4% 5.2% 3.1% 40.2% 11.3%
OR 0.18 0.69 2.71 5.57 0.84
95% CI 0.02–1.73 0.13–3.62 0.24–30.38 0.62–50.05 0.40–1.77
p value

0.14
0.66
0.42
0.13
0.64
>71 sCJD 317 57.0% 5.2% 10.1% 49.2% 12.4%
Control 60 65.0% 6.7% 10.0% 56.7% 11.7%
OR 0.81 0.76 1.15 0.83 1.27
95% CI 0.15–4.37 0.15–3.80 0.38–3.48 0.17–4.02 0.52–3.10
p value 0.80 0.74 0.81 0.82 0.60

*sCJD, sporadic Creutzfeldt-Jakob disease; OR, odds ratio; CI, confidence interval.

Main Article

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