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Volume 15, Number 3—March 2009

CME ACTIVITY

Clinical Risk Factors for Severe Clostridium difficile–associated Disease

Timothy J. HenrichComments to Author , Douglas Krakower, Asaf Bitton, and Deborah S. Yokoe
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (T.J. Henrich, D. Krakower, A. Bitton, D.S. Yokoe); Massachusetts General Hospital, Boston (D. Krakower); Harvard Medical School, Boston (Deborah S. Yokoe)

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Table 5

Binary logistic regression model to identify independent associations of laboratory values and pertinent variables with severe CDAD, 285 patients*

Variable OR 95% CI
Age >70 y 3.24† 1.42–7.38
Female 1.16 0.51–2.62
Antimicrobial-drug use 1.04 0.35–3.12
Malignancy 0.90 0.37–2.18
Chemotherapy 1.02 0.27–3.92
Steroid use 1.13 0.48–2.68
Hemodialysis 0.5 0.8–3.01
Max leukocyte count >20,000/μL 2.77† 1.28–6.0
Max glucose level >150 mg/dL 1.46 0.63–3.43
ALT >40 U/L 1.47 0.58–3.69
Min albumin level <2.5 g/dL 3.44† 1.56–7.57
Max creatinine level >2 mg/dL 2.47† 1.04–5.88

*CDAD, Clostridium difficile–associated disease; OR, odds ratio; CI, confidence interval; max, maximum; ALT, alanine aminotransferase; min, minimum. Constant included in analysis.
†p<0.05.

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