Emerging Infectious Disease ISSN: 1080-6059

Evaluation of Commercially Available Anti–Dengue Virus Immunoglobulin M Tests

Elizabeth A. Hunsperger, Sutee Yoksan, Philippe Buchy, Vinh Chau Nguyen, Shamala D. Sekaran, Delia A. Enria, Jose L. Pelegrino, Susana Vázquez, Harvey Artsob, Michael Drebot, Duane J. Gubler, Scott B. Halstead, María G. Guzmán, Harold S. Margolis, Carl-Michael Nathanson, Nidia R. Rizzo Lic, Kovi E. Bessoff, Srisakul Kliks, and Rosanna W. Peeling

Author affiliations: Centers for Disease Control and Prevention, San Juan, Puerto Rico, USA (E.A. Hunsperger, K.E. Bessoff); Mahidol University, Bangkok, Thailand (S. Yoksan); Institut Pasteur, Phnom Penh, Cambodia (P. Buchy); Cho Quan Hospital, Ho Chi Minh City, Vietnam (V.C. Nguyen); University of Malaya, Kuala Lumpur, Malaysia (S.D. Sekaran); Instituto Nacional Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Buenos Aires, Argentina (D.A. Enria); Instituto Medicina Tropical Pedro Kouri, Havana, Cuba (S. Vázquez, M.G. Guzmán, J.L. Pelegrino); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (H. Artsob, M. Drebot); University of Hawaii, Honolulu, Hawaii, USA (D.J. Gubler); Pediatric Dengue Vaccine Initiative, Seoul, South Korea (S.B. Halstead, H.S. Margolis, S. Kliks); World Health Organization, Geneva, Switzerland (C.-M. Nathanson, N.R. Rizzo, R.W. Peeling)

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Figure 1

A) Sensitivity and B) specificity of 5 microplate ELISAs used at laboratories in 7 countries for detecting immunoglobulin (Ig) M against dengue virus compared with reference solid-phase IgM antibody-capture ELISAs developed by the Centers for Disease Control and Prevention (Atlanta, GA, USA) and the Armed Forces Research Institute of Medical Science (Bangkok, Thailand). Mean sensitivities and specificities for the 5 tests are shown in parentheses. C) Sensitivity and D) specificity of 4 rapid dia

Figure 1. A) Sensitivity and B) specificity of 5 microplate ELISAs used at laboratories in 7 countries for detecting immunoglobulin (Ig) M against dengue virus compared with reference solid-phase IgM antibody-capture ELISAs developed by the Centers for Disease Control and Prevention (Atlanta, GA, USA) and the Armed Forces Research Institute of Medical Science (Bangkok, Thailand). Mean sensitivities and specificities for the 5 tests are shown in parentheses. C) Sensitivity and D) specificity of 4 rapid diagnostic tests used at laboratories in 7 countries for detecting IgM against dengue virus compared with solid-phase IgM antibody-capture ELISAs. Mean sensitivities and specificities for the 4 tests are shown in parentheses.

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