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Volume 15, Number 3—March 2009

Dispatch

Evaluation of Commercially Available Anti–Dengue Virus Immunoglobulin M Tests

Elizabeth A. Hunsperger, Sutee Yoksan, Philippe Buchy, Vinh Chau Nguyen, Shamala D. Sekaran, Delia A. Enria, Jose L. Pelegrino, Susana Vázquez, Harvey Artsob, Michael Drebot, Duane J. Gubler, Scott B. Halstead, María G. Guzmán, Harold S. Margolis, Carl-Michael Nathanson, Nidia R. Rizzo Lic, Kovi E. Bessoff, Srisakul Kliks, and Rosanna W. PeelingComments to Author 
Author affiliations: Centers for Disease Control and Prevention, San Juan, Puerto Rico, USA (E.A. Hunsperger, K.E. Bessoff); Mahidol University, Bangkok, Thailand (S. Yoksan); Institut Pasteur, Phnom Penh, Cambodia (P. Buchy); Cho Quan Hospital, Ho Chi Minh City, Vietnam (V.C. Nguyen); University of Malaya, Kuala Lumpur, Malaysia (S.D. Sekaran); Instituto Nacional Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Buenos Aires, Argentina (D.A. Enria); Instituto Medicina Tropical Pedro Kouri, Havana, Cuba (S. Vázquez, M.G. Guzmán, J.L. Pelegrino); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (H. Artsob, M. Drebot); University of Hawaii, Honolulu, Hawaii, USA (D.J. Gubler); Pediatric Dengue Vaccine Initiative, Seoul, South Korea (S.B. Halstead, H.S. Margolis, S. Kliks); World Health Organization, Geneva, Switzerland (C.-M. Nathanson, N.R. Rizzo, R.W. Peeling)

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Table 1

Panels used for evaluation of 350 serum samples from patients with positive and negative results for IgM to DENV*

Evaluation panel No. samples
DENV IgM positive
From primary infections 27
From secondary infections 154
Total positive
181†
DENV IgM negative
DENV positive/DENV IgM negative 19
DENV IgG positive
7
Related flavivirus IgM positive
West Nile virus positive 25
Yellow fever virus positive
4
Related flavivirus IgG positive
West Nile virus positive 1
Yellow fever virus positive 10
St. Louis encephalitis virus positive 2
Japanese encephalitis virus positive
10
Febrile illness
Lyme disease IgG positive 9
Malaria 31
New World hantavirus IgM positive
7
Systemic conditions
Rheumatoid factor 6
Systemic lupus erythematosus
2
Healthy persons‡
Negative
36
Total negative 169

*DENV, dengue virus; Ig, immunoglobulin.
†No. serum samples identified as serotype specific: 26 DENV-1, 19 DENV-2, 13 DENV-3, and 7 DENV-4. Serotype was not identified for 116 samples.
‡From areas where dengue is not endemic.

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