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Volume 15, Number 4—April 2009

Research

Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children

Qingfu Xu, Michael E. Pichichero, Janet R. Casey, and Mingtao ZengComments to Author 
Author affiliations: University of Rochester School of Medicine and Dentistry, Rochester, New York, USA (Q. Xu, M.E. Pichichero, M. Zeng); Legacy Pediatrics, Rochester (M.E. Pichichero, J.R. Casey)

Main Article

Table 2

Comparison of Streptococcus pneumoniae ST-2722 (Legacy strain) with the closest types that have 6 of the same alleles as ST-2722*

ST Serotypes Allele profile of housekeeping genes†
No. resistant/ total strains Countries of isolation Sources
aroE gdh gki recP spi xpt ddl
156 9V/14/11A/ 15C/19F 7 11 10 1 6 8 1 38/59 BR, CA, CZ, DK, FR, DE, HU, IL, IT, LB, NL, PL, SE, PT, QA, ES, UK, UY Nasopharynx, cerebrospinal fluid, blood, pleural, sputum, ear
1556 14 7 11 10 12 6 8 1 1/1 DE Blood
1697 9V 7 11 10 77 6 8 1 1 UK NA
2684 11A 7 11 10 10 6 8 1 1/1 FR Nasopharynx
334 9 7 11 10 16 6 8 1 1/1 NO Blood
1893 14 7 11 10 4 6 8 1 1 NO NA
2616 14 7 11 10 2 6 8 1 1 ES Nasopharynx
1227 14 7 11 10 29 6 8 1 1/1 SE Nasopharynx
2128 9 7 11 10 5 6 8 1 1/1 UK Blood
2722 19A 7 11 10 15 6 8 1 1 US Ear

*Types reported in the multilocus sequence typing database (http://spneumoniae.mlst.net). ST, sequence type; BR, Brazil; CA, Canada; CZ, Czech Republic; DE, Germany; DK, Denmark; FR, France; HU, Hungary; IL, Israel; IT, Italy; LB, Lebanon; NL, Netherlands; NO, Norway; PL, Poland; SE, Sweden; PT, Portugal; QA, Qatar; ES, Spain; UK, United Kingdom; UY, Uruguay; US, United States; NA, not available.
aroE (shikimate dehydrogenase), gdh (glucose-6-phosphate dehydrogenase), gki (glucose kinase), recP (transketolase), spi (signal peptidase I), xpt (xanthine phosphoribosyltransferase), and ddl (D-alanine-D-alanine ligase).

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