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Volume 15, Number 4—April 2009

Dispatch

Genetic Diversity of Toscana Virus

Ximena Collao12, Gustavo Palacios1, Sara Sanbonmatsu-Gámez, Mercedes Pérez-Ruiz, Ana I. Negredo, José-María Navarro-Marí, Marc Grandadam, Ana Maria Aransay, W. Ian Lipkin, Antonio Tenorio3, and María-Paz Sánchez-Seco3Comments to Author 
Author affiliations: Columbia University, New York, New York, USA (G. Palacios, W.I. Lipkin); University Hospital “Virgen de las Nieves,” Granada, Spain (S. Sanbonmatsu-Gámez, M. Pérez-Ruiz, J.-M. Navarro-Marí); Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France (M. Grandadam); Centro de Investigacion Cooperation bioGUNE, Vizcaya, Spain (A.M. Aransay)

Main Article

Table

Sequence differences among phleboviruses*

Comparison Similarity of sequences (amino acid similarity), mean % ± SD
L segment M segment NS gene N gene
Within TOSV 91.7 ± 0.7 (98.8 ± 0.5) 92.4 ± 0.6 (95.4 ± 0.9) 90.7 ± 0.8 (95.8 ± 1) 95.9 ± 0.8 (100)
Within TOSV A NA 99.3 ± 0.1 (99.4 ± 0.5) NA 100 (100)
Within TOSV B 98.2 ± 0.2 (99.7 ± 0.1) 95.5 ± 0.4 (98.2 ± 0.5) 97.3 ± 0.4 (98.5 ± 0.5) 98.5 ± 0.3 (100)
Between TOSV A and TOSV B 85.2 ±0.4 (97.0 ± 0.4) 81.8 ± 0.4 (90.0 ± 1.1) 83.6 ± 1.1 (89.6 ± 1.6) 87.9 ± 1.4 (100)
Within TOSV A G1 to G4 NA 99.3 ± 0.1 (99.3 ± 0.2) NA NA
Between TOSV A G1, G2, G3, and G4 NA 95.6 ± 0.4 (97.3 ± 0.5) NA NA
Within RVFV 97.7 ± 0.3 (99.8 ± 0.1) 95.4 ± 0.5 (98.6 ± 0.5) 97.2 ± 0.3 (98.5 ± 0.4) 97.6 ± 0.5 (99.8 ± 0.1)
Within RVFV lineages 98.8 ± 0.1 (99.5 ± 0.1) 98.8 ± 0.1 (99.5 ± 0.1) 98.8 ± 0.2 (99.1 ± 0.3) 99.1 ± 0.2 (99.9 ± 0.1)
Between RVFV lineages 96.6 ± 0.2 (99.2 ± 0.2) 96.6 ± 0.2 (99.1 ± 0.2) 97.0 ± 0.5 (98.0 ± 0.6) 97.5 ± 0.5 (99.6 ± 0.3)
Within SFSV NA 76.5 ± 1.3 (80.2 ± 2.1) 99.7 ± 0.2 (98.9 ± 0.7) 100 (100)
Within SFNV NA 72.2 ± 1.2 (72.9 ± 2.1) NA NA
Within PTV 96.5 ± 0.7 (100) 92.5 ± 0.8 (97.5 ± 0.9) 87.6 ± 1.4 (94.2 ± 1.6) 100 (100)
Between SFSV and PTV NA 45.5 ± 1.8 (32.3 ± 3.2) 40.2 ± 1.9 (23.7 ± 3.1) 55.0 ± 3.6 (52.5 ± 6.4)
Between SFNV and TOSV NA 57.2 ± 1.7 (53.6 ± 3.1) NA 78.8 ± 2.8 (93.2 ± 3.3)

*Based on complete genome sequences. To estimate the evolutionary divergence over sequence pairs between groups, the average number of nucleotide differences per site over all sequence pairs between groups and among groups was calculated. Standard error estimates were obtained by a bootstrap procedure (500 replicates). For each pairwise sequence comparison, all positions containing alignment gaps and missing data were eliminated. L, large; M, medium; NS, nonstructural; N, nucleoprotein; TOSV, Toscana virus; NA, not applicable; RVFV, Rift Valley fever virus; SFSV, sandfly fever Sicilian virus; SFNV, sandfly fever Naples virus; PTV, Punta Toro virus.

Main Article

1,3These pairs of authors contributed equally to this work

2Current affiliation: Valparaíso University, Valparaíso, Chile

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