TY - JOUR AU - Ruppé, Etienne AU - Hem, Sopheak AU - Lath, Sovannarith AU - Gautier, Valérie AU - Ariey, Frédéric AU - Sarthou, Jean-Louis AU - Monchy, Didier AU - Arlet, Guillaume T1 - CTX-M β-Lactamases in Escherichia coli from Community-acquired Urinary Tract Infections, Cambodia T2 - Emerging Infectious Disease journal PY - 2009 VL - 15 IS - 5 SP - 741 SN - 1080-6059 AB - Despite the recent global spread of CTX-M β-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, we documented the prevalence of extended-spectrum β-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. We observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. U using repetitive extragenic palindromic–PCR, we identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M β-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries. KW - Antimicrobial resistance KW - bacteria KW - enteric infections KW - Escherichia coli KW - community KW - urinary tract infections KW - β-lactamase resistance KW - developing countries KW - Cambodia KW - research DO - 10.3201/eid1505.071299 UR - https://wwwnc.cdc.gov/eid/article/15/5/07-1299_article ER - End of Reference