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Volume 15, Number 5—May 2009

Dispatch

Molecular Epidemiology of Feline and Human Bartonella henselae Isolates

Rim Bouchouicha, Benoit Durand, Martine Monteil, B.B. Chomel, Moez Berrich, Mardjan Arvand, Richard J. Birtles, Edward B. Breitschwerdt, Jane E. Koehler, Ricardo G. Maggi, Soichi Maruyama, Rick Kasten, Elisabeth Petit, Henri-Jean Boulouis, and Nadia HaddadComments to Author 
Author affiliations: Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France (R. Bouchouicha, M. Monteil, M. Berrich, E. Petit, H.-J. Boulouis, N. Haddad); Agence Française de Sécurité Sanitaire des Aliments, Maisons Alfort (B. Durand); University of California, Davis, California, USA (B. Chomel, R. Kasten); Zentrum für Gesundheitsschutz, Dillenburg, Germany (M. Arvand); University of Liverpool, Cheshire, UK (R.J. Birtles); North Carolina State University, Raleigh, North Carolina, USA (E. Breitschwerdt, R. Maggi); University of California, San Francisco, California, USA (J. Koehler); Nihon University, Kanagawa, Japan (S. Maruyama)

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Table 1

Description of Bartonella henselae isolates and strains tested, global diversity of the typing system, and diversity variations according to 16S rDNA genotype, continent, and host*

Characteristics No. isolates/ strains No. profiles Average no. isolates/profiles DI No. alleles (minimum–maximum no. repeats)
A B C D E
All B. henselae 178 99 1.8 0.98 8
(9–16) 22
(5–37) 14
(1–25) 8
(1–9) 7
(1–7)
16S rDNA genotype I 64 44 1.5 0.98 6 12 11 6 6
16S rDNA genotype II
114
55
2.0
0.97
6
15
7
7
6
Location
Europe 80† 42 1.9 0.95 6 12 6 6 5
Asia 29‡ 22 1.3 0.98 7 10 8 4 3
USA 49§ 28 1.7 0.95 4 12 7 6 6
Australia–New Zealand
20¶
11
1.8
0.87
4
5
5
4
6
Host
Human + dog 22# 12 1.8 0.87 2 6 6 3 6
Healthy cat 156 92 1.7 0.98 8 20 11 8 7

*DI, diversity index; A, BHV-A; B, BHV-B; C, BHV-C; D, BHV-D; E, BHV-E.
†Denmark, 18 (7); France, 23 (7); Germany, 27 (2); UK, 12 (5).
‡Japan, 12 (8); Philippines, 7 (9); Thailand, 10 (10).
§California: 36, including 5 owners and their 11 cats (6,14); North Carolina, 12 (provided by Ed Breitschwerdt). Reference strain Houston 1.
¶Australia, 18 and New Zealand, 2 (3,12).
#21 human isolates from 1 German patient with bacillary angiomatosis (BA) (2), 1 Japanese patient with cat-scratch disease (provided by S. Maruyama), 12 Australian human patients with cat-scratch disease (3), 5 California human patients with BA (14), 1 North Carolina patient with a wide range of symptoms, including fatigue, joint pain, insomnia, headache, blurred vision, irritability (provided by Ed Breitschwerdt), plus the reference strain Houston 1 (ATCC 49882, initially isolated from a patient with BA) (3), and 1 isolate from a dog with endocarditis (provided by Ed Breitschwerdt).

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