Emerging Infectious Disease ISSN: 1080-6059

Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Kazuaki Takahashi

, Hiroaki Okamoto, Natsumi Abe, Manri Kawakami, Hiroyuki Matsuda, Satoshi Mochida, Hiroshi Sakugawa, Yoshiki Suginoshita, Seishiro Watanabe, Kazuhide Yamamoto, Yuzo Miyakawa, and Shunji Mishiro

Author affiliations: Toshiba General Hospital, Tokyo, Japan (K. Takahashi, N. Abe, S. Mishiro); Jichi Medical University School of Medicine, Tochigi, Japan (H. Okamoto); Kurashiki Medical Center, Okayama, Japan (M. Kawakami); Matsuda Naika Clinic, Tottori, Japan (H. Matsuda); Saitama Medical University, Saitama, Japan (S. Mochida); Heart-Life Hospital, Okinawa, Japan (H. Sakugawa); Kyoto University Graduate School of Medicine, Kyoto, Japan (Y. Suginoshita); Kagawa Prefectural Central Hospital, Kagawa, Japan (S. Watanabe); Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama (K. Yamamoto); Miyakawa Memorial Research Foundation, Tokyo (Y. Miyakawa)

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Figure 2

A) Phylogenetic tree (unweighted pair-grouping method with arithmetic means) constructed on the complete or near-complete nucleotide sequences of hepatitis E virus (HEV) genotype 3 isolates. Clustering of nucleotide sequences of 8 human patients infected with JIO strain of HEV and 5 swine infected with swJ19 strain of HEV is boxed by a solid line. Another clustering of local genotype 3 isolates from Hyogo Prefecture, Japan, is boxed by a dotted line. B) Phylogenetic tree (unweighted pair-groupin

Figure 2. A) Phylogenetic tree (unweighted pair-grouping method with arithmetic means) constructed on the complete or near-complete nucleotide sequences of hepatitis E virus (HEV) genotype 3 isolates. Clustering of nucleotide sequences of 8 human patients infected with JIO strain of HEV and 5 swine infected with swJ19 strain of HEV is boxed by a solid line. Another clustering of local genotype 3 isolates from Hyogo Prefecture, Japan, is boxed by a dotted line. B) Phylogenetic tree (unweighted pair-grouping method with arithmetic means) constructed on a partial sequence of 412 nt in open reading frame (ORF) 2 (nt 5994-6405 of the US2 genome) of HEV genotype 3. Partial nucleotide sequences of 8 human JIO and 11 swine HEV swJI9 isolates (accession nos. AB094279–AB094289) are shown (shading). Analyses of full sequences of 5 of these 11 swine isolates were performed (swJ19-1, swJ19-2, swJ19-5, swJ19-7, and swJ19-8). Scale bars indicate nucleotide substitutions per site; boldface indicates isolates from humans.

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