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Volume 15, Number 5—May 2009

Research

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers1, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. TellingComments to Author 
Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Main Article

Figure 1

Levels of transgene expression in transgenic (Tg) mice expressing deer or elk cellular prion protein (PrPC). Representative Western blot analysis of PrPC expression from different total protein loads in brain extracts from Tg mice Tg(CerPrP)1536+/–, Tg(CerPrP-E226)5029+/–, and Tg(CerPrP-E226)5037+/– compared with wild type and Prnp0/0 mice (knock-out mice for PrP gene).

Figure 1. Levels of transgene expression in transgenic (Tg) mice expressing deer or elk cellular prion protein (PrPC). Representative Western blot analysis of PrPC expression from different total protein loads in brain extracts from Tg mice Tg(CerPrP)1536+/–, Tg(CerPrP-E226)5029+/–, and Tg(CerPrP-E226)5037+/– compared with wild type and Prnp0/0 mice (knock-out mice for PrP gene).

Main Article

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