Volume 15, Number 5—May 2009

Research

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers¹, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. Telling 

Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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Figure 1

Figure 1. Levels of transgene expression in transgenic (Tg) mice expressing deer or elk cellular prion protein (PrP^C). Representative Western blot analysis of PrP^C expression from different total protein loads in brain extracts from Tg mice Tg(CerPrP)1536^+/–, Tg(CerPrP-E226)5029^+/–, and Tg(CerPrP-E226)5037^+/– compared with wild type and Prnp^0/0 mice (knock-out mice for PrP gene).

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