Chronic Wasting Disease Prions in Elk Antler Velvet
Rachel C. Angers1, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. Telling
Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Figure 1. Levels of transgene expression in transgenic (Tg) mice expressing deer or elk cellular prion protein (PrPC). Representative Western blot analysis of PrPC expression from different total protein loads in brain extracts from Tg mice Tg(CerPrP)1536+/–, Tg(CerPrP-E226)5029+/–, and Tg(CerPrP-E226)5037+/– compared with wild type and Prnp0/0 mice (knock-out mice for PrP gene).
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