Emerging Infectious Disease ISSN: 1080-6059

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers¹, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. Telling

Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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Figure 2

Accumulation of PrPSc (disease-associated form of prion protein) in diseased transgenic (Tg) mice. Tg(CerPrP)1536+/– and Tg(CerPrPE226)5037+/– mice inoculated with phosphate-buffered saline (PBS), elk brain (B), or antler velvet (A) were treated with or without proteinase K (PK). Membranes were probed with monoclonal antibody 6H4. Molecular weights indicated are 37, 29, and 20 kD.

Figure 2. Accumulation of PrP^Sc (disease-associated form of prion protein) in diseased transgenic (Tg) mice. Tg(CerPrP)1536^+/– and Tg(CerPrPE226)5037^+/– mice inoculated with phosphate-buffered saline (PBS), elk brain (B), or antler velvet (A) were treated with or without proteinase K (PK). Membranes were probed with monoclonal antibody 6H4. Molecular weights indicated are 37, 29, and 20 kD.

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