Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 15, Number 5—May 2009

Research

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers1, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. TellingComments to Author 
Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Main Article

Figure 4

PrPSc (disease-associated form of prion protein)–specific immunohistochemistry in the brains of diseased mice. Transgenic (Tg) mice Tg(CerPrP)1536+/– inoculated with brain (A) and antler velvet (B) preparations from elk 01-0306 exhibit florid PrPSc-reactive plaques in the cerebral cortex at the level of the thalamus but retain integrity of cerebellar granular cells (C and D). Tg(CerPrP-E226)5037+/– mice inoculated with brain (E) and antler velvet (F) preparations from elk 01-0306 display small p

Figure 4. PrPSc (disease-associated form of prion protein)–specific immunohistochemistry in the brains of diseased mice. Transgenic (Tg) mice Tg(CerPrP)1536+/– inoculated with brain (A) and antler velvet (B) preparations from elk 01-0306 exhibit florid PrPSc-reactive plaques in the cerebral cortex at the level of the thalamus but retain integrity of cerebellar granular cells (C and D). Tg(CerPrP-E226)5037+/– mice inoculated with brain (E) and antler velvet (F) preparations from elk 01-0306 display small plaques and diffuse granular staining in the cerebral cortex, PrPSc deposition, and marked cerebellar neuronal loss (G and H).

Main Article

TOP