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Volume 15, Number 7—July 2009

Research

Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis1

William J. BurmanComments to Author , Erin E. Bliven, Lauren Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
Author affiliations: Denver Public Health, Denver Colorado, USA (W.J. Burman); University of Colorado at Denver Health Sciences Center, Denver (W.J. Burman); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.E. Bliven, L. Cowan, L. Bozeman, L. Diem, A. Vernon); The University of California, San Francisco, California, USA (P. Nahid)

Main Article

Table 1

Characteristics of case-patients and controls, Tuberculosis Trials Consortium Study 22*

Characteristic Case-patients (treatment failure or relapse), n = 64† Controls (patients cured), n = 296† Odds ratio (95% confidence interval) p value
Demographic
Age, y, mean (SD) 42 (13) 44 (14) 1.0 (0.97–1.01) 0.51
Men
54 (84)
214 (72)
2.1 (1.0–4.3)
0.05
Treatment
Rifapentine, 1×/wk 40 (63) 151 (51) 1.6 (0.9–2.8) 0.10
Rifampin, 2×/wk
24 (37)
145 (49)


Ethnic origin
Non-Hispanic white 22 (34) 43 (15) 3.1 (1.7–5.7) 0.0002
Non-Hispanic black 25 (39) 127 (43) 0.9 (0.5–1.5) 0.57
Hispanic 9 (14) 71 (24) 0.5 (0.2–1.1) 0.08
Asian–Pacific Islander 6 (9) 45 (15) 0.6 (0.2–1.4) 0.23
Native American
2 (3)
10 (3)
0.9 (0.2–4.3)
0.92
Birthplace
United States or Canada 48 (75) 200 (68) 1.4 (0.8–2.7) 0.24
Mexico 5 (8) 36 (12) 0.6 (0.2–1.6) 0.32
Europe 2 (3) 4 (1) 2.4 (0.4–13.1) 0.31
Southeast Asia 2 (3) 6 (2) 1.6 (0.3–7.9) 0.59
Western Pacific 4 (6) 33 (11) 0.5 (0.2–1.6) 0.24
Other
3 (5)
17 (6)
0.8 (0.2–2.8)
0.74
Baseline clinical features
Fever 50/62 (81) 166/289 (57) 3.1 (1.6–6.0) 0.0007
Sweats 42/63 (67) 162/287 (56) 1.5 (0.9–2.7) 0.14
Cough 61 (95) 256/294 (87) 3.0 (0.9–10.1) 0.06
Underweight‡ 38 (59) 82 (28) 3.8 (2.2–6.7) <0.0001
Sputum smear positive
55 (86)
193/292 (66)
3.1 (1.5–6.6)
0.002
Baseline chest radiographic features
Cavitation 54 (84) 146/287 (51) 5.2 (2.6–10.6) <0.0001
Bilateral pulmonary involvement
50 (78)
155/293 (53)
3.2 (1.7–6.0)
0.0002
Two-month sputum analysis
Smear positive 16 (25) 30/285 (11) 2.8 (1.4–5.6) 0.002
Culture positive
33 (54)
48/267 (18)
5.4 (3.0–9.7)
<0.0001
Mycobacterium tuberculosis lineage/family
East Asian/Beijing 15 (23) 42 (14) 1.9 (0.9–3.6) 0.07
Euro-American 47 (73) 221 (75) 0.9 (0.5–1.7) 0.84
Indo-Oceanic 0 25 (8.5) 0.08 (0.01–1.4) 0.01
East African 1 (1.6) 3 (1.0) 1.6 (0.16–15.1) 0.54
Unclassified lineage 1 (1.6) 5 (1.7) 0.9 (0.11–8.04) 1.00

*The Tuberculosis Trials Consortium Study enrolled patients during 1995–1998. Participants in the case–control study were selected from among 1,004 HIV-infected participants.
†Except for age, values are no. (%) or no. positive/no. tested (%).
‡Less than 10% below ideal bodyweight at diagnosis.

Main Article

1This study was presented in part at the 2008 International Conference of the American Thoracic Society, May 16–21, 2008, Toronto, Ontario, Canada.

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