Volume 15, Number 9—September 2009
Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
|No. monkeys||CWD inoculum||Route of inoculation||Titer inoculated†||Current mpi|
|1 (no. 609)‡||MD-1||Intracerebral||2.5 × 106||NA|
|1||MD-1||Intracerebral||2.5 × 106||70|
|3||MD-1||Oral||2.0 × 109||70|
|2||Elk-1||Intracerebral||3.2 × 105||70|
|3||Elk-1||Oral||2.5 × 108||70|
|2||WTD-1||Intracerebral||1.0 × 106||70|
|3||WTD-1||Oral||1.2 × 109||70|
*CWD, chronic wasting disease; mpi, months postinfection; NA, not available.
†Infectivity titers were determined by using endpoint dilution titer in transgenic deer expressing mouse prion protein and are listed as the total 50% infectious dose/g of brain.
‡Monkey 609 was euthanized at 48 mpi, and no protease-resistant prion protein was detected by Western blot or immunohistochemical analysis.
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