TY - JOUR AU - Dutil, Lucie AU - Irwin, Rebecca AU - Finley, Rita AU - Ng, Lai King AU - Avery, Brent AU - Boerlin, Patrick AU - Bourgault, Anne-Marie AU - Cole, Linda AU - Daignault, Danielle AU - Desruisseau, Andrea AU - Demczuk, Walter AU - Hoang, Linda AU - Horsman, Greg B. AU - Ismail, Johanne AU - Jamieson, Frances AU - Maki, Anne AU - Pacagnella, Ana AU - Pillai, Dylan R. T1 - Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 1 SP - 48 SN - 1080-6059 AB - The Canadian Integrated Program for Antimicrobial Resistance Surveillance describes a strong correlation (r = 0.9, p<0.0001) between ceftiofur-resistant Salmonella enterica serovar Heidelberg isolated from retail chicken and incidence of ceftiofur-resistant Salmonella serovar Heidelberg infections in humans across Canada. In Québec, changes of ceftiofur resistance in chicken Salmonella Heidelberg and Escherichia coli isolates appear related to changing levels of ceftiofur use in hatcheries during the study period, from highest to lowest levels before and after a voluntary withdrawal, to increasing levels after reintroduction of use (62% to 7% to 20%, and 34% to 6% to 19%, respectively). These events provide evidence that ceftiofur use in chickens results in extended-spectrum cephalosporin resistance in bacteria from chicken and humans. To ensure the continued effectiveness of extended-spectrum cephalosporins for treating serious infections in humans, multidisciplinary efforts are needed to scrutinize and, where appropriate, limit use of ceftiofur in chicken production in Canada. KW - Salmonella enterica serovar Heidelberg KW - Escherichia coli KW - antimicrobial resistance KW - humans KW - chickens KW - Canada KW - bacteria KW - expedited KW - research DO - 10.3201/eid1601.090729 UR - https://wwwnc.cdc.gov/eid/article/16/1/09-0729_article ER - End of Reference