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Volume 16, Number 1—January 2010

Research

Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter baumannii1

Pauline D. Mugnier, Laurent Poirel, Thierry Naas, and Patrice NordmannComments to Author 
Author affiliations: Institut National de la Santé et de la Recherche Médicale Unité 914, Paris, France; Université Paris Sud, Bicêtre, France; 1This work was presented in part at the 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, May 16–19, 2009.

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Table

Characteristics of 20 blaOXA-23-positive Acinetobacter baumannii clinical isolates*

Isolate Origin Date of isolation Specimen EC ST† Copy no. of blaOXA-23 Genetic location and size, kb Genetic structure MIC, μg/mL
CAZ IPM MEM
240 France 2003 Dec Tracheal aspirate II 22/2 1 Chromosome, ≈200‡ Tn2006 128 >32 >32
512 Tahiti 2004 Mar Tracheal aspirate II 22/2 1 Chromosome, ≈200‡ Tn2006 64 >32 >32
761 Vietnam 2005 May Bile II 22/2 1 Chromosome, ≈200‡ Tn2006 64 >32 >32
810 New Caledonia 2004 Jun Blood II 22/2 1 Chromosome, ≈200‡ Tn2006 96 >32 >32
863 Thailand 2006 Jun Urine II 22/2 1 Chromosome, ≈200‡ Tn2006 256 >32 >32
883 Reunion 2006 Jun Unknown II 22/2 1 Chromosome, ≈200‡ Tn2006 128 >32 >32
Ab13 France 2004 Jun Urine II 22/2 2 Chromosome, ≈200,‡ and plasmid, 70 Tn2006 128 >32 >32
AUS Australia 2004 Oct Urine II 22/2 1 Chromosome, ≈200‡ Tn2006 96 >32 >32
859 South Africa 2006 Jan Urine II 22/2 1 Chromosome, ≈200‡ Tn2006 128 >32 >32
585 France 2004 Jul Tracheal aspirate II 53/2 1 Chromosome, ≈200‡ Tn2006 128 >32 >32
614 Libya 2004 Oct Unknown I 25/20 1 Plasmid, 130 Tn2008 256 >32 16
AS3 UAE† 2006 Oct Blood I 25/20 1 Plasmid, 130 ISAba1 256 >32 >32
1190 Bahrain 2008 Mar Blood I 25/20 1 Plasmid, 130 ISAba1 256 >32 >32
AS1 UAE 2006 Jul Blood I 44/1 1 Chromosome, ≈40‡ Tn2006 256 >32 >32
Ab14 Algeria 2004 Dec Unknown I 44/1 2 Plasmid, 25, and plasmid, >150 Tn2007 4 16 >32
910 Reunion 2006 Oct Unknown I New1/1 1 Plasmid, 130 Tn2006 256 16 16
861 Egypt 2005 Nov Sputum I New1/ 1 1 Plasmid, 130 ISAba1 8 32 32
BEL Belgium 2007 Jul Respiratory tract I New2/ 1 2 Plasmid, 25, and plasmid, >150 Tn2007 256 >32 >32
DOS France 2004 May Unknown New3/ New 2 Plasmid, 25, and plasmid, >150 Tn2007 8 >32 >32
877 Brazil 2006 Jul Wound New4/15 1 Plasmid, 130 ISAba1 96 >32 >32

*EC, European clone; ST, sequence type; UAE, United Arab Emirates; CAZ, ceftazidime; IPM, imipenem; MEM, meropenem. The MIC for ticarcillin was >256 μg/mL for all 20 isolates.
†ST determined by Bartual et al. (19) compared with ST determined by Nemec et al. (20).
‡Size of chromosome band carrying the blaOXA-23 gene, as determined by using the I-CeuI technique.

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