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Volume 16, Number 10—October 2010

Research

Therapeutic Drug Monitoring for Slow Response to Tuberculosis Treatment in a State Control Program, Virginia, USA

Scott K. HeysellComments to Author , Jane L. Moore, Suzanne J. Keller, and Eric R. Houpt
Author affiliations: Author affiliations: University of Virginia, Charlottesville, Virginia, USA (S.K. Heysell, E.R. Houpt); Virginia Department of Health, Richmond, Virginia, USA (J.L. Moore, S.J. Keller)

Main Article

Table 3

Risk factors for INH or RIF serum concentration levels below the expected range 2 hours after medication administration among persons with slow responses, therapeutic drug monitoring, Virginia, USA, March 1, 2007–May 1, 2009*

Characteristic Normal INH,
n = 16,
no. (%) Low INH, n = 23,
no. (%) Bivariate risk ratio (95% CI); p value Normal RIF,
n = 20,
no. (%) Low RIF,
n = 22,
no. (%) Bivariate risk ratio (95% CI); p value
Age, y
18–39 4 (25) 8 (35) Referent 5 (25) 10 (46) Referent
40–64 7 (44) 8 (35) 0.57 (0.12–2.80); p = 0.49 8 (40) 7 (32) 0.44 (0.10–1.90); p = 0.27
>65
5 (31)
7 (30)
0.70 (0.13–3.70); p = 0.67
7 (35)
5 (22)
0.36 (0.07–1.70); p = 0.20
Sex
M 11 (69) 15 (65) Referent 13 (65) 15 (68) Referent
F
5 (31)
8 (35)
1.2 (0.30–4.60); p = 0.82
7 (35)
7 (32)
0.87 (0.24–3.10); p = 0.81
Race/Ethnicity
White 1 (6) 3 (13) 1.9 (0.16–22.30); p = 0.61 3 (15) 1(5) 0.37 (0.3–4.2); p = 0.42
Asian 7 (44) 11 (48) Referent 10 (50) 9 (41) Referent
Hispanic/Latino 6 (38) 4 (17) 0.42 (0.09–2.10); p = 0.43 3 (15) 8 (36) 3.0 (0.60–14.70); p = 0.18
Black
2 (12)
5 (22)
1.6 (0.24–10.60); p = 0.63
4(20)
4 (18)
1.1 (0.21–5.80); p = 0.90
Foreign-born
No 3 (19) 6 (26) Referent 6 (30) 3 (14) Referent
Yes
13 (81)
17 (74)
0.65 (0.14–3.10); p = 0.59
14 (70)
19 (86)
2.7 (0.58–12.80); p = 0.21
Diabetes
No 10 (63) 13 (57) Referent 16 (80) 9 (41) Referent
Yes
6 (37)
10 (43)
1.3 (0.35–4.70); p = 0.71
4 (20)
13 (59)
5.8 (1.4–23.1); p = 0.01†
Alcohol abuse
No 15 (94) 22 (96) Referent 18 (90) 20 (91) Referent
Yes
1 (6)
1 (4)
0.69 (0.40–11.70); p = 0.79
2 (10)
2 (9)
0.90 (0.12–7.10); p = 0.92
Dose interval
Daily 8 (50) 19 (83) Referent 11 (65) 16 (73) Referent
Biweekly 8 (50) 4 (17) 0.21 (0.05–0.90); p = 0.04‡ 6 (35) 6 (27) 0.88 (0.23–3.30); p = 0.85

*INH, isoniazid; RIF, rifampin; CI, confidence interval. Low is defined as below expected range; normal is defined as within or above expected range.
†Adjusted odds ratio 5.7 (1.2–25.7); p = 0.03.
‡Adjusted odds ratio 0.47 (0.09–2.50); p = 0.37.

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