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Volume 16, Number 10—October 2010

Research

Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore

Mark I.C. ChenComments to Author , Vernon J.M. Lee, Ian G. Barr, Cui Lin, Rachelle Goh, Caroline Lee, Baldev Singh, Jessie Tan, Wei-Yen Lim, Alex R. Cook, Brenda Ang, Angela Chow, Boon Huan Tan, Jimmy Loh, Robert Shaw, Kee Seng Chia, Raymond T.P. Lin, and Yee Sin Leo
Author affiliations: Author affiliations: Tan Tock Seng Hospital, Singapore (M.I.C. Chen, R. Goh, C. Lee, B. Singh, J. Tan, B. Ang, A. Chow, Y.S. Leo); Duke-National University of Singapore Graduate Medical School, Singapore (M.I.C. Chen); Ministry of Defence, Singapore (V.J.M. Lee); World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (I. Barr, R. Shaw); National Public Health Laboratory, Singapore (C. Lin, R.T.P. Lin); National University of Singapore, Singapore (W.-Y. Lim, A.R. Cook, K.S. Chia); DSO National Laboratories, Singapore (B.H. Tan, J. Loh)

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Table 3

Multivariate analysis of risk factors associated with seroconversion for pandemic (H1N1) 2009 in 531 healthcare workers, Singapore, 2009*

Risk factor Adjusted OR (95% CI) p value
Occupational subgroup
Allied health Referent
Nurses 4.5 (1.0–19.6) 0.05
Ancilllary and support 1.5 (0.2–11.1) 0.69
Administration 3.6 (0.3–42.8) 0.31
Doctors
3.8 (0.5–28.7)
0.19
Pandemic (H1N1) 2009 isolation wards vs. all others 4.5 (1.3–15.6) 0.02
Contact with colleague(s) who had pandemic (H1N1) 2009 vs. none 2.5 (0.9–6.6) 0.06
Household size (per additional household member) 1.2 (1.0–1.4) 0.06
HI titer in baseline sample (per unit of increase)† 0.5 (0.3–1.0) 0.05

*OR, odds ratio; CI, confidence interval; HI, hemagglutination inhibition.
†For every unit increase in baseline (sample A) titer, where the integer values of 0–8 denote titers <0, 10, 20, 40, 80, 160, 320, 640, and >1,280, respectively.

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