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Volume 16, Number 10—October 2010

Research

Oral Fluid Testing during 10 Years of Rubella Elimination, England and Wales

Gayatri Manikkavasagan, Antoaneta Bukasa, Kevin E. Brown, Bernard J. Cohen, and Mary E. RamsayComments to Author 
Author affiliations: Author affiliation: Health Protection Agency Centre for Infections, London, UK

Main Article

Table 1

Accuracy of World Health Organization–modified clinical case definition for rubella, England and Wales, 1999–2008*


Characteristic
Sensitivity

Specificity

Positive predictive value
No. positive/ no. tested
% (95% CI)
No. positive/ no. tested
% (95% CI)
No. positive/ no. tested
% (95% CI)
Age, y
<1 22/37 59.5 (43.6–75.3) 1,467/2,804 52.3 (50.5–54.2) 22/1,359 1.6 (1.0–2.3)
1–4 34/75 45.3 (34.1–56.6) 2,303/4,522 50.9 (49.5–52.4) 34/2,253 1.5 (1.0–2.0)
5–9 7/11 63.6 (35.2–92.1) 1,006/1,640 61.3 (59.0–63.7) 7/641 1.1 (0.3–1.9)
10–14 10/32 31.3 (15.2–47.3) 298/426 70.0 (65.6–74.3) 10/138 7.2 (2.9–11.6)
15–24 433/871 49.7 (46.4–53.0) 281/462 60.8 (56.4–65.3) 433/614 70.5 (66.9–74.1)
>25
256/455
56.3 (51.7–60.8)

257/439
58.5 (53.9–63.2)

256/438
58.4 (53.8–63.1)
Sex
M 649/1,278 50.8 (48.0–53.5) 2,877/5,326 54.0 (52.7–55.4) 649/3,098 20.9 (19.5–22.4)
F
112/202
55.4 (48.6–62.3)

2,744/4,954
55.3 (54.0–56.8)

112/2,322
4.8 (3.95–5.7)
Year of report
1995 Jan–1998 Dec 743/1,435 51.8 (49.2–54.4) 3,630/6,677 54.4 (53.2–55.6) 743/3,790 19.6 (18.3–20.9)
1999 Jan–2003 Jul 18/46 39.1 (25.0–53.2) 1,983/3,616 54.8 (53.2–56.5) 18/1,651 1.1 (0.6–1.6)

*CI, confidence interval.

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