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Volume 16, Number 11—November 2010

Dispatch

Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus

Priyasma Bhoumik and Austin L. HughesComments to Author 
Author affiliations: Author affiliation: University of South Carolina, Columbia, South Carolina, USA

Main Article

Table 2

Mean ± SE gene diversity at synonymous and nonsynonymous polymorphic nucleotide sites in hemagglutinin and neuraminidase genes of influenza A virus serotypes*

Genotype HA
NA
Synonymous Nonsynonymous Synonymous Nonsynonymous
Pandemic H1N1 (2009) 0.0120 ± 0.0007 [173] 0.0112 ± 0.0006 [839] 0.2535 ± 0.0173 [179] 0.0863 ± 0.0060 [706]†
H1N1 (pre-2009) 0.0798 ± 0.0063 [198] 0.0506 ± 0.0019 [814]† 0.0765 ± 0.0083 [152] 0.0453 ± 0.0017 [712]†
H3N2 0.0710 ± 0.0086 [203] 0.0331 ± 0.0030 [793]† 0.0760 ± 0.0087 [177] 0.0332 ± 0.0029 [688]†
H5N1 0.1195 ± 0.0106 [184] 0.0552 ± 0.0027 [834]† 0.1120 ± 0.0098 [157] 0.0482 ± 0.0024 [645]†

*HA, hemagglutinin; NA, neuraminidase. Numbers of polymorphic nucleotide sites are indicated in brackets.
†Gene diversity at nonsynonymous sites significantly different from that at synonymous sites (p<0.001; randomization test).

*HA, hemagglutinin; NA, neuraminidase. Numbers of polymorphic nucleotide sites are indicated in brackets.
†Gene diversity at nonsynonymous sites significantly different from that at synonymous sites (p<0.001; randomization test).

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