TY - JOUR AU - Rebaudet, Stanislas AU - Bogreau, Hervé AU - Silaï, Rahamatou AU - Lepère, Jean-François AU - Bertaux, Lionel AU - Pradines, Bruno AU - Delmont, Jean AU - Gautret, Philippe AU - Parola, Philippe AU - Rogier, Christophe T1 - Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 11 SP - 1686 SN - 1080-6059 AB - The efficacy of malaria control and elimination on islands may depend on the intensity of new parasite inflow. On the Comoros archipelago, where falciparum malaria remains a major public health problem because of spread of drug resistance and insufficient malaria control, recent interventions for malaria elimination were planned on Moheli, 1 of 4 islands in the Comoros archipelago. To assess the relevance of such a local strategy, we performed a population genetics analysis by using multilocus microsatellite and resistance genotyping of Plasmodium falciparum sampled from each island of the archipelago. We found a contrasted population genetic structure explained by geographic isolation, human migration, malaria transmission, and drug selective pressure. Our findings suggest that malaria elimination interventions should be implemented simultaneously on the entire archipelago rather than restricted to 1 island and demonstrate the necessity for specific chemoresistance surveillance on each of the 4 Comorian islands. KW - Plasmodium falciparum, malaria KW - elimination, control, population genetics, molecular epidemiology, parasitic diseases, drug resistance, Comoros, research KW - Comoros DO - 10.3201/eid1611.100694 UR - https://wwwnc.cdc.gov/eid/article/16/11/10-0694_article ER - End of Reference