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Volume 16, Number 11—November 2010

Dispatch

Experimental Pandemic (H1N1) 2009 Virus Infection of Cats

Judith M.A. van den Brand, Koert J. Stittelaar, Geert van Amerongen, Marco W.G. van de Bildt, Lonneke M.E. Leijten, Thijs Kuiken, and Albert D.M.E. OsterhausComments to Author 
Author affiliations: Erasmus Medical Centre, Rotterdam, the Netherlands (J.M.A. van den Brand, K.J. Stittelaaar, G. van Amerongen, M.W.G. van de Bildt, L.M.E. Leijten, T. Kuiken, A.D.M.E. Osterhaus); ViroClinics Biosciences BV, Rotterdam (K.J. Stittelaar, G. van Amerongen, A.D.M.E. Osterhaus)

Main Article

Table

Test results for 8 cats intratracheally infected with pandemic (H1N1) 2009 virus*

Tissue source No. positive
IHC analysis
Virus isolation†
4 dpi 7 dpi 4 dpi 7 dpi
Respiratory
Lung 4 3 4 1
Bronchus 2 0 4 0
Trachea 0 0 4 1
Nasal turbinates
0
0

2
0
Extrarespiratory
Liver 0 0 0 1
Intestine 0 0 1 1
Olfactory bulb 0 0 0 1
Brain 0 0 0 1
Spleen 0 0 1 0
Tonsil 0 0 2 0
Adrenal gland 0 0 0 2
Nictitating membrane 0 0 0 2

*Four cats were examined on each day. IHC, immunohistochemical; dpi, days postinfection.
†No virus was isolated from tracheobronchial lymph node, pancreas, heart, or kidney of any cats.

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