TY - JOUR AU - Alzahrani, Abdullah G. AU - Al Shaiban, Hassan M. AU - Al Mazroa, Mohammad A. AU - Al-Hayani, Osama AU - MacNeil, Adam AU - Rollin, Pierre E. AU - Memish, Ziad A. T1 - Alkhurma Hemorrhagic Fever in Humans, Najran, Saudi Arabia T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 12 SP - 1882 SN - 1080-6059 AB - Alkhurma virus is a flavivirus, discovered in 1994 in a person who died of hemorrhagic fever after slaughtering a sheep from the city of Alkhurma, Saudi Arabia. Since then, several cases of Alkhurma hemorrhagic fever (ALKHF), with fatality rates up to 25%, have been documented. From January 1, 2006, through April 1, 2009, active disease surveillance and serologic testing of household contacts identified ALKHF in 28 persons in Najran, Saudi Arabia. For epidemiologic comparison, serologic testing of household and neighborhood controls identified 65 serologically negative persons. Among ALKHF patients, 11 were hospitalized and 17 had subclinical infection. Univariate analysis indicated that the following were associated with Alkhurma virus infection: contact with domestic animals, feeding and slaughtering animals, handling raw meat products, drinking unpasteurized milk, and being bitten by a tick. After multivariate modeling, the following associations remained significant: animal contact, neighboring farms, and tick bites. KW - Alkhurma virus KW - Alkhurma hemorrhagic fever KW - Flavivirus KW - Saudi Arabia KW - hemorrhagic fever KW - tickborne KW - livestock KW - viruses KW - zoonoses KW - research DO - 10.3201/eid1612.100417 UR - https://wwwnc.cdc.gov/eid/article/16/12/10-0417_article ER - End of Reference