Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 16, Number 12—December 2010

CME ACTIVITY

Pandemic (H1N1) 2009 Infection in Patients with Hematologic Malignancy

Catherine LiuComments to Author , Brian S. Schwartz, Snigdha Vallabhaneni, Michael Nixon, Peter V. Chin-Hong, Steven A. Miller, Charles Chiu, Lloyd Damon, and W. Lawrence Drew
Author affiliations: Author affiliation: University of California, San Francisco, California, USA

Main Article

Table 1

Characteristics of hematologic malignancy patients with URTI or LRTI and pandemic (H1N1) 2009 virus, University of California, San Francisco, Medical Center, San Francisco, California, USA, June–December 2009*

Characteristic Total, n = 27 URTI, n = 17 LRTI, n = 10 p value†
Median age, y (range) 43 (5–83) 33 (5–83) 53 (29–80) 0.04
Male sex
18 (67)
10 (59)
8 (80)
0.24
Underlying malignancy
Acute lymphocytic leukemia 6 (22) 5 (29) 1 (10) 0.25
Acute myelocytic leukemia 5 (19) 4 (24) 1 (10) 0.37
Chronic lymphocytic leukemia 1 (4) 1 (6) 0 0.63
Lymphoma 6 (22) 2 (12) 4 (40) 0.11
Multiple myeloma 7 (26) 4 (24) 3 (30) 0.52
Other
2 (7)
1 (6)
1 (10)
0.61
Hematopoietic cell transplant 18 (67) 12 (71) 6 (60) 0.44
Allogeneic 7 (39) 4 (33) 3 (50) 0.43
Graft-vs.-host disease 6 (86) 3 (75) 3 (100) 0.57
Autologous 11 (61) 8 (67) 3 (50) 0.43
Median time posttransplant, mo (range)
12 (0.3–45)
12 (3–45)
11 (0.3–34)
0.81
Immunosuppressive medications
Corticosteroid use 7 (26) 2 (12) 5 (50) 0.04
T-/B-cell depleting agent
4 (15)
1 (6)
3 (30)
0.13
Underlying concurrent conditions
Obesity, body mass index >30 kg/m2 2 (7) 0 2 (20) 0.13
Chronic lung disease 5 (19) 1 (6) 4 (40) 0.047
Diabetes mellitus 6 (22) 1 (6) 5 (50) 0.015
HIV infection 2 (7) 1 (6) 1(10) 0.61

*Values are given as no. (%) patients except as indicated. URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection.
†p value represents statistical difference between comparison of values of patients with LRTI and URTI.

Main Article

TOP