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Volume 16, Number 12—December 2010

CME ACTIVITY - Research

Pandemic (H1N1) 2009 Infection in Patients with Hematologic Malignancy

Catherine LiuComments to Author , Brian S. Schwartz, Snigdha Vallabhaneni, Michael Nixon, Peter V. Chin-Hong, Steven A. Miller, Charles Chiu, Lloyd Damon, and W. Lawrence Drew
Author affiliations: Author affiliation: University of California, San Francisco, California, USA

Main Article

Table 1

Characteristics of hematologic malignancy patients with URTI or LRTI and pandemic (H1N1) 2009 virus, University of California, San Francisco, Medical Center, San Francisco, California, USA, June–December 2009*

Characteristic Total, n = 27 URTI, n = 17 LRTI, n = 10 p value†
Median age, y (range) 43 (5–83) 33 (5–83) 53 (29–80) 0.04
Male sex
18 (67)
10 (59)
8 (80)
0.24
Underlying malignancy
Acute lymphocytic leukemia 6 (22) 5 (29) 1 (10) 0.25
Acute myelocytic leukemia 5 (19) 4 (24) 1 (10) 0.37
Chronic lymphocytic leukemia 1 (4) 1 (6) 0 0.63
Lymphoma 6 (22) 2 (12) 4 (40) 0.11
Multiple myeloma 7 (26) 4 (24) 3 (30) 0.52
Other
2 (7)
1 (6)
1 (10)
0.61
Hematopoietic cell transplant 18 (67) 12 (71) 6 (60) 0.44
Allogeneic 7 (39) 4 (33) 3 (50) 0.43
Graft-vs.-host disease 6 (86) 3 (75) 3 (100) 0.57
Autologous 11 (61) 8 (67) 3 (50) 0.43
Median time posttransplant, mo (range)
12 (0.3–45)
12 (3–45)
11 (0.3–34)
0.81
Immunosuppressive medications
Corticosteroid use 7 (26) 2 (12) 5 (50) 0.04
T-/B-cell depleting agent
4 (15)
1 (6)
3 (30)
0.13
Underlying concurrent conditions
Obesity, body mass index >30 kg/m2 2 (7) 0 2 (20) 0.13
Chronic lung disease 5 (19) 1 (6) 4 (40) 0.047
Diabetes mellitus 6 (22) 1 (6) 5 (50) 0.015
HIV infection 2 (7) 1 (6) 1(10) 0.61

*Values are given as no. (%) patients except as indicated. URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection.
†p value represents statistical difference between comparison of values of patients with LRTI and URTI.

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