Volume 16, Number 12—December 2010
CME ACTIVITY
Pandemic (H1N1) 2009 Infection in Patients with Hematologic Malignancy
Catherine Liu
, Brian S. Schwartz, Snigdha Vallabhaneni, Michael Nixon, Peter V. Chin-Hong, Steven A. Miller, Charles Chiu, Lloyd Damon, and W. Lawrence Drew
, Brian S. Schwartz, Snigdha Vallabhaneni, Michael Nixon, Peter V. Chin-Hong, Steven A. Miller, Charles Chiu, Lloyd Damon, and W. Lawrence DrewTable 1
Characteristics of hematologic malignancy patients with URTI or LRTI and pandemic (H1N1) 2009 virus, University of California, San Francisco, Medical Center, San Francisco, California, USA, June–December 2009*
| Characteristic | Total, n = 27 | URTI, n = 17 | LRTI, n = 10 | p value† |
|---|---|---|---|---|
| Median age, y (range) | 43 (5–83) | 33 (5–83) | 53 (29–80) | 0.04 |
| Male sex |
18 (67) |
10 (59) |
8 (80) |
0.24 |
| Underlying malignancy | ||||
| Acute lymphocytic leukemia | 6 (22) | 5 (29) | 1 (10) | 0.25 |
| Acute myelocytic leukemia | 5 (19) | 4 (24) | 1 (10) | 0.37 |
| Chronic lymphocytic leukemia | 1 (4) | 1 (6) | 0 | 0.63 |
| Lymphoma | 6 (22) | 2 (12) | 4 (40) | 0.11 |
| Multiple myeloma | 7 (26) | 4 (24) | 3 (30) | 0.52 |
| Other |
2 (7) |
1 (6) |
1 (10) |
0.61 |
| Hematopoietic cell transplant | 18 (67) | 12 (71) | 6 (60) | 0.44 |
| Allogeneic | 7 (39) | 4 (33) | 3 (50) | 0.43 |
| Graft-vs.-host disease | 6 (86) | 3 (75) | 3 (100) | 0.57 |
| Autologous | 11 (61) | 8 (67) | 3 (50) | 0.43 |
| Median time posttransplant, mo (range) |
12 (0.3–45) |
12 (3–45) |
11 (0.3–34) |
0.81 |
| Immunosuppressive medications | ||||
| Corticosteroid use | 7 (26) | 2 (12) | 5 (50) | 0.04 |
| T-/B-cell depleting agent |
4 (15) |
1 (6) |
3 (30) |
0.13 |
| Underlying concurrent conditions | ||||
| Obesity, body mass index >30 kg/m2 | 2 (7) | 0 | 2 (20) | 0.13 |
| Chronic lung disease | 5 (19) | 1 (6) | 4 (40) | 0.047 |
| Diabetes mellitus | 6 (22) | 1 (6) | 5 (50) | 0.015 |
| HIV infection | 2 (7) | 1 (6) | 1(10) | 0.61 |
*Values are given as no. (%) patients except as indicated. URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection.
†p value represents statistical difference between comparison of values of patients with LRTI and URTI.
