TY - JOUR AU - Tijet, Nathalie AU - Tang, Patrick AU - Romilowych, Mya AU - Duncan, Carla AU - Ng, Victoria AU - Fisman, David N. AU - Jamieson, Frances AU - Low, Donald E. AU - Guyard, Cyril T1 - New Endemic Legionella pneumophila Serogroup I Clones, Ontario, Canada T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 3 SP - 447 SN - 1080-6059 AB - The water-borne pathogen Legionella pneumophila serogroup 1 (Lp1) is the most commonly reported etiologic agent of legionellosis. To examine the genetic diversity, the long-term epidemiology, and the molecular evolution of Lp1 clinical isolates, we conducted sequence-based typing on a collection of clinical isolates representing 3 decades of culture-confirmed legionellosis in Ontario, Canada. Analysis showed that the population of Lp1 in Ontario is highly diverse and combines lineages identified worldwide with local strains. Identical types were identified in sporadic and outbreak-associated strains. In the past 15 years, the incidence of some lineages distributed worldwide has tended to decrease, and local endemic clones and lineages have emerged. Comparative geographic distribution analysis suggests that some lineages are specific to eastern North America. These findings have general clinical implications for the study of Lp1 molecular evolution and for the identification of Lp1 circulating strains in North America. KW - Legionella pneumophila serogroup 1 KW - molecular epidemiology KW - sequence-based typing KW - phylogeny KW - clonal analysis KW - emerging clones KW - bacteria KW - Canada KW - research DO - 10.3201/eid1603.081689 UR - https://wwwnc.cdc.gov/eid/article/16/3/08-1689_article ER - End of Reference