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Volume 16, Number 3—March 2010

Research

Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany

Johannes EliasComments to Author , Leo M. Schouls, Ingrid van de Pol, Wendy C. Keijzers, Diana R. Martin, Anne Glennie, Philipp Oster, Matthias Frosch, Ulrich Vogel1, and Arie van der Ende1
Author affiliations: University of Wuerzburg, Wuerzburg, Germany (J. Elias, M. Frosch, U. Vogel); National Institute for Public Health and Environment (RIVN), Bilthoven, the Netherlands (L.M. Schouls, I. van de Pol); Academic Medical Center, Amsterdam, the Netherlands (W.C. Keijzers, A. van der Ende); Institute of Environmental Science and Research, Porirua, New Zealand (D.R. Martin, A. Glennie); Novartis Vaccines, Siena, Italy (P. Oster)

Main Article

Table 1

Positively and negatively correlating MLVA-MLST pairs, Neisseria meningitis clone, Greater Aachen Region, Germany, 2001–2006*

Association MT ST N NEXP N (MT] N (ST] J JEXP p value
Positive
19 42 91 38 209 209 0.2783 0.1013 0
30 40 19 3 38 82 0.1881 0.0235 0
78 1374 25 2 54 39 0.3676 0.0199 0
27
40
18
4
59
82
0.1452
0.032
0.00002
Negative 27 41 3 16 60 292 0.0086 0.0462 0
30 42 1 7 38 209 0.0041 0.0287 0
78 41 4 14 54 292 0.0117 0.0416 0.00004

*MLVA, multilocus variable tandem repeat analysis; MLST, multilocus sequent type; MT, MLVA type; ST, multi-locus-sequence type, N, no. strains with MT and ST; NEXP, expected number of strains with MT and ST; N (MT], no.strains with MT; N (ST], no. strains with ST; J, Jaccard index; JEXP, expected Jaccard index; p, 2-tailed p values (see text).

Main Article

1These authors contributed equally to this article.

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