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Volume 16, Number 3—March 2010

Dispatch

Experimental Infection of Squirrel Monkeys with Nipah Virus

Philippe Marianneau1, Vanessa Guillaume1, K. Thong Wong, Munisamy Badmanathan, Ren Yih Looi, Séverine Murri, Philippe Loth, Noël Tordo, T. Fabian Wild, Branka HorvatComments to Author , and Hugues Contamin
Author affiliations: Institut Pasteur, Lyon, France (P. Marianneau, S. Murri, P. Loth, N. Tordo, H. Contamin); Institut national de santé et de la recherché médicale, Lyon (V. Guillaume, T.F. Wild, B. Horvat); University of Malaya, Kuala Lumpur, Malaysia (K.T. Wong, M. Badmanathan, R.Y. Looi)

Main Article

Table 1

Clinical course of Nipah virus infection in 12 squirrel monkeys*

Monkey Mode of
infection Dose, PFU/mL Day of 1st symptoms Duration of clinical state Day of euthanasia Clinical state at euthanasia Clinical signs
A† IV 103 3 Well None
B IV 103 10 3 12† Moribund Uncoordinated motor movements, prostration and coma
C IV 103 19 3 21‡ Moribund Uncoordinated motor movements, prostration, and coma
D† IV 107 3 Well None
E IV 107 7 2 8† Moribund Uncoordinated motor movements, prostration, and coma
F IV 107 14 3 52 Recovered/well Anorexia, depression
G† IN 103 4 Well None
H IN 103 52 Well None
I IN 103 8 3 56 Recovered/well Anorexia, seizure
J† IN 107 4 Well None
K IN 107 17 Septic shock not correlated with NiV infection
L IN 107 10 7 56 Recovered/well Anorexia, seizure, edema of eyes

*IV, intravenous; IN, intranasal; NiV, Nipah virus.
†Early systematic euthanasia.
‡Death caused by NiV infection.

Main Article

1These authors contributed equally to this article.

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