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Volume 16, Number 3—March 2010

Dispatch

Quinine-Resistant Malaria in Traveler Returning from Senegal, 2007

Bruno Pradines, Thierry Pistone, Khaled EzzedineComments to Author , Sébastien Briolant, Lionel Bertaux, Marie-Catherine Receveur, Daniel Parzy, Pascal Millet, Christophe Rogier, and Denis Malvy
Author affiliations: Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France (B. Pradines, S. Briolant, L. Bertaux, D. Parzy, C. Rogier); Centre Hospitalier Universitaire St.-André, Bordeaux, France (T. Pistone, K. Ezzedine, M.-C. Receveur, D. Malvy); Université Victor Segalen Bordeaux 2, Bordeaux (K. Ezzedine, P. Millet, D.Malvy)

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Table

In vitro susceptibility of 3 Plasmodium falciparum isolates to 12 antimalarial drugs, France*

Drug 50% Inhibitory concentration
Study isolate 3D7 W2 Cutoff value
Quinine 829 nmol/L 157 nmol/L 574 nmol/L >800 nmol/L
Chloroquine 472 nmol/L 21 nmol/L 392 nmol/L >100 nmol/L
Mefloquine 10.4 nmol/L 49.3 nmol/L 39.3 nmol/L >30 nmol/L
Lumefantrine 19 nmol/L 29 nmol/L 35 nmol/L >150 nmol/L
Monodesethylamodiaquine 47 nmol/L 17 nmol/L 162 nmol/L >80 nmol/L
Dihydroartemisinin 1.1 nmol/L 2.5 nmol/L 3.0 nmol/L >10.5 nmol/L
Atovaquone 13.3 nmol/L 4.1 nmol/L 3.6 nmol/L >350 nmol/L
Cycloguanil 70 nmol/L <10 nmol/L 1191 nmol/L >500 nmol/L
Pyrimethamine 354 nmol/L <50 nmol/L 9139 nmol/L >2,000 nmol/L
Doxycycline 12.8 μmol/L 10.5 μmol/L 13.5 μmol/L >35 μmol/L
Azithromycin 24 μmol/L 48 μmol/L 39 μmol/L ND
Clindamycin 39 μmol/L 108 μmol/L 126 μmol/L ND

*P. falciparum strains 3D7 and W2 were used as controls. ND, not determined.

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