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Volume 16, Number 4—April 2010

Dispatch

Fluoroquinolone Resistance and Clostridium difficile, Germany

Nils Henning ZaißComments to Author , Wolfgang Witte, and Ulrich Nübel
Author affiliations: Robert Koch Institute, Wernigerode, Germany

Main Article

Table 2

Resistance to moxifloxacin and levofloxacin among the 5 PCR ribotypes of Clostridium difficile most common in Germany, 2008

PCR ribotype (no.) No. (%) isolates, resistant to moxifloxacin (MIC >4 mg/L) No. (%) isolates, resistant to levofloxacin (MIC >4 mg/L) Amino acid substitution
GyrA GyrB
001 (303) 301 (99) 301 (99) Thr-82-Ile, Asp-71-Glu
078 (46) 29 (63) 30 (65) Thr-82-Ile, Thr-82-Ala Asp-426-Asn
027 (51) 51 (100) 51 (100) Thr-82-Ile
014 (21) 2 (9) 2 (9) Thr-82-Ile Glu-466-Lys
046 (14) 14 (100) 14 (100) Thr-82-Ile

Main Article

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