Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice
Figure 7. Topologic distribution of antigens in mice infected with influenza A virus subtype H1N1 at day 7 postinfection (left columns) and subtype H5N1 at day 4 postinfection (right columns) in various nonrespiratory organs. A) Glial cells (mostly oligodendrocytes); B) cardiomyocytes; C) spleen macrophages; D) hepatocytes; E) islets of Langerhans cells in the pancreas; and F) adipocytes. Bright virus-positive staining can be seen in subtype H5N1–infected mice (antinucleoprotein immunohistochemical staining), while absence of any staining can be seen in subtype H1N1–infected mice (Mayer hematoxylin counterstain). Original magnification ×100.