Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice
Mutien-Marie Garigliany, Adélite Habyarimana, Bénédicte Lambrecht, Els Van de Paar, Anne Cornet, Thierry van den Berg, and Daniel Desmecht
Author affiliations: University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht); Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).
Figure 7. Topologic distribution of antigens in mice infected with influenza A virus subtype H1N1 at day 7 postinfection (left columns) and subtype H5N1 at day 4 postinfection (right columns) in various nonrespiratory organs. A) Glial cells (mostly oligodendrocytes); B) cardiomyocytes; C) spleen macrophages; D) hepatocytes; E) islets of Langerhans cells in the pancreas; and F) adipocytes. Bright virus-positive staining can be seen in subtype H5N1–infected mice (antinucleoprotein immunohistochemical staining), while absence of any staining can be seen in subtype H1N1–infected mice (Mayer hematoxylin counterstain). Original magnification ×100.
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