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Volume 16, Number 4—April 2010


Reassortment of Human Rotavirus Gene Segments into G11 Rotavirus Strains

Jelle MatthijnssensComments to Author , Mustafizur Rahman, Max Ciarlet, Mark Zeller, Elisabeth Heylen, Toyoko Nakagomi, Ryuichi Uchida1, Zahid Hassan, Tasnim Azim, Osamu Nakagomi, and Marc Van Ranst
Author affiliations: Rega Institute for Medical Research, Leuven, Belgium (J. Matthijnssens, M. Zeller, E. Heylen, M. Van Ranst); International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh (M. Rahman, Z. Hassan, T. Azim); Merck and Company, Inc., North Wales, Pennsylvania, USA (M. Ciarlet); Nagasaki University, Nagasaki, Japan (T. Nakagomi, R. Uchida, O. Nakagomi); 1Current affiliation: Osaka University, Osaka, Japan.

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Table 2

Subcluster-based genomic constellations of G11 human rotavirus strains, 3 porcine strains, and human reference strain Wa*

Hu/Wa G1 P[8] I1 R1 C1 M1 A1 N1 T1 E1 H1
Hu/KTM368 G11 P[25] I12 R1 C1 M1 A1 N1 T1 E1 H1
Hu/Dhaka6 G11 P[25] I1 R1 C1 M1 A1 N1 T1 E1 H1
Hu/Matlab36–02 G11 P[8] I1 R1 C1 M1 A1 N1 T1 E1 H1
Po/YM G11 P[7] I5 R1 C1 M1 A8 N1 T1 E1 H1
Po/Gottfried G4 P[6] I1 R1 C1 M1 A8 N1 T1 E1 H1
Po/OSU G5 P[7] I5 R1 C1 M1 A1 N1 T1 E1 H1

*VP, structural protein; NSP, nonstructural protein; Hu, human; Po, porcine. Genotypes belonging to the Wa genogroup indicated in green in Table 1 are further subdivided into subclusters shown in green, purple, and light blue, based on phylogenetic trees shown in online Technical Appendix 2 to distinguish additional patterns. G11 and the rare P[25] and I12 genotypes are indicated in orange, and typical porcine genotypes are indicated in dark blue.

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