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Volume 16, Number 6—June 2010

Research

Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan

Yoshiro MuraseComments to Author , Shinji Maeda, Hiroyuki Yamada, Akihiro Ohkado, Kinuyo Chikamatsu, Kazue Mizuno, Seiya Kato, and Satoshi Mitarai
Author affiliations: The Research Institute of Tuberculosis/Japan Anti-Tuberculosis Association, Tokyo, Japan

Main Article

Table 1

Comparison of characteristics between TB patients with XDR TB and non-XDR MDR TB from the most recent (2002) nationwide drug susceptibility survey, Japan*

Characteristic No. (%) cases
Odds ratio (95% confidence interval)
XDR, 
n = 17 Non–XDR MDR, n = 38 MDR/XDR, n = 55 Drug susceptible, n = 2,782 MDR/XDR vs. drug susceptible XDR vs. non–XDR MDR
Age, y
0–20 0 1 (3) 1 (2) 51 (2) 2.57 (–)
21–40 6 (35) 14 (37) 20 (36) 460 (17) 5.69 (2.63–12.45) 0.51 (0.12–2.18)
41–60 10 (59) 12 (32) 22 (40) 701 (25) 4.11 (1.93–8.85) 1
>61
1 (6)
11 (29)
12 (22)
1,570 (56)

1
0.11 (0.00–1.11)
Sex
M 9 (53) 30 (79) 39 (71) 1,973 (71) 1 1
F
8 (47)
8 (21)
16 (29)
809 (29)

1.00 (0.53–1.86)
3.33 (0.83–13.77)
Nationality
Japanese 16 (94) 31 (82) 47 (85) 2,710 (97) 1 1
Foreigner
1 (6)
7 (18)
8 (15)
72 (3)

6.41 (2.69–14.72)
0.28 (0.01–2.64)
Treatment history
New 8 (47) 17 (45) 25 (45) 2,498 (90) 1 1
Previous
9 (53)
21 (55)
30 (55)
284 (10)

10.55 (5.93–18.83)
0.91 (0.25–3.33)
Site of TB
Pulmonary 17 (100) 38 (100) 55 (100) 2,687 (97)
Extrapulmonary
0
0
0
95 (3)



Chest radiograph finding
Noncavitary 5 (29) 8 (21) 13 (24) 1,394 (50) 1 1
Cavitary
12 (71)
30 (79)
42 (76)
1,388 (50)

3.24 (1.68–6.38)
0.64 (0.15–2.84)
Sputum smear test result
Negative 3 (18) 6 (16) 9 (16) 838 (30) 1 1
Positive
14 (82)
32 (84)
46 (84)
1,944 (70)

2.20 (1.03–4.85)
0.88 (0.16–5.23)
Complication
None 6 (35) 21 (55) 27 (49) 1,344 (48) 1
Diabetes mellitus 4 (24) 7 (18) 11 (20) 438 (16) 1.25 (0.58–2.65) 2.00 (0.34–11.88)
Malignancy 3 (18) 2 (5) 5 (9) 180 (6) 1.38 (0.46–3.83) 5.25 (0.52–61.86)

*TB, tuberculosis; XDR, extensively drug-resistant; MDR, multidrug-resistant; MDR/XDR, MDR TB and XDR TB; –, not available. Boldface indicates significance.

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