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Volume 16, Number 7—July 2010

Synopsis

Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia

Adrian R. TramontanaComments to Author , Biju George, Aeron C. Hurt, Joseph S. Doyle, Katherine Langan, Alistair B. Reid, Janet M. Harper, Karin Thursky, Leon J. Worth, Dominic E Dwyer, C. Orla Morrissey, Paul D.R. Johnson, Kirsty L. Buising, Simon James Harrison, John F. Seymour, Patricia E. Ferguson, Bin Wang, Justin T. Denholm, Allen C. Cheng, and Monica Slavin
Author affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (A.R. Tramontana, K. Thursky, L.J. Worth, S.J. Harrison, J.F. Seymour, M. Slavin); Western Hospital, Footscray, Victoria, Australia (A.R. Tramontana); Westmead Hospital, Sydney, New South Wales, Australia (B. George, D.E. Dwyer, B. Wang), World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt); The Alfred Hospital, Prahran, Victoria, Australia (J.S. Doyle, C.O. Morrissey); Austin Health, Heidelberg, Victoria, Australia (K. Langan, P.D.R. Johnson); St. Vincent’s Hospital, Melbourne, Victoria, Australia (A.B. Reid, K.L. Buising); Royal Melbourne Hospital, Melbourne (J.M. Harper, J.T. Denholm, M. Slavin); Centre for Infectious Diseases and Microbiology, Sydney (P.E. Ferguson); Monash University, Prahran (A.C. Cheng)

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Table 1

Demographics and clinical findings among patients who had malignancy or HSCT and influenza A pandemic (H1N1) 2009 virus, Australia*

Patient no. Age, y/sex Underlying malignancy Coexisting conditions Acquisition Radiographic infiltrates ICU Death
Allogeneic stem cell transplant recipients
1 44/F Prolymphocytic leukemia GVHD, renal Community† None Yes Yes
2 53/F Non-Hodgkin lymphoma GVHD‡ Nosocomial Multifocal Yes Yes
3 33/M Hodgkin lymphoma None Community None No No
4 57/F CML GVHD§ Community Unifocal No No
5 61/M Myelodysplastic syndrome None Nosocomial Multifocal Yes Yes
6 56/M Myelofibrosis GVHD‡ Community Multifocal Yes Yes
7 61/M AML GVHD,§ cardiac Community None No No
8
63/F
AML
None
Nosocomial
Unifocal
Yes
No
Autologous stem cell transplant recipients
9 70/M Multiple myeloma Pulmonary Community† Unifocal Yes No
10 50/F Multiple myeloma None Community Multifocal Yes Yes
11 72/M Multiple myeloma Type 2 diabetes Community None No No
12 42/F Multiple myeloma Type 2 diabetes Community Multifocal Yes No
13 57/M Multiple myeloma None Community† Multifocal No No
14 30/F Hodgkins lymphoma None Community Multifocal No No
15 52/F Non-Hodgkins lymphoma None Community None No No
16
68/M
Multiple myeloma
Renal
Community
Multifocal
Yes
Yes
Patients with no prior stem cell transplant
17 24/F Hodgkins lymphoma None Community¶ None No No
18 72/M AML Type 2 diabetes Community Multifocal No No
19 63/F Multiple myeloma None Community Multifocal No No
20 80/F Aplastic anemia Cardiac Community None No No
21 70/F Hodgkins lymphoma None Community None No No
22 61/F CLL None Community† Multifocal No No
23 63/F Non-Hodgkin lymphoma Pulmonary Community† None No No
24 68/M CLL Pulmonary Community None Yes Yes
25 76/M CLL Pulmonary Community Multifocal No No
26 59/F AML None Community None No No
27 47/F CLL None Community No imaging No No
28 57/M Multiple myeloma None Community Unifocal No No
29 56/M Hodgkin lymphoma Type 2 diabetes Community Multifocal No No
30 26/M ALL None Nosocomial No imaging No No
31 55/F Cervical cancer None Community None No No
32 50/F Breast cancer None Community Multifocal No No

*HSCT, hematopoietic stem cell transplant; ICU, intensive care unit; GVHD, graft-versus-host disease; CML, chronic myeloid leukemia; AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; ALL, acute lymphocytic leukemia.
†Household contacts with influenza-like illness identified.
‡Severe GVHD.
§Chronic GVHD.
¶Patient 17 had onset of influenza-like symptoms on returning to Victoria from interstate travel.

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