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Volume 16, Number 7—July 2010

Research

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Cesar G. Albariño1Comments to Author , Gustavo Palacios1, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek2, W. Ian Lipkin, and Stuart T. Nichol
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.G. Albariño, M.L. Khristova, B.R. Erickson, S.A. Carroll, J.A. Comer, T.G. Ksiazek, S.T. Nichol); Columbia University, New York, New York, USA (G. Palacios, J. Hui, T. Briese, W.I. Lipkin); New York State Department of Health, Albany, New York, USA (K. St. George)

Main Article

Table 2

Genetic diversity of lymphocytic choriomeningitis virus strains*

Diversity RNA, nt
Proteins, aa
L S Z L GPC N
Overall 22 19 18 13 10 6
Within lineage I 19 15 15 11 6 4
Within lineage II 25 15 34 18 7 3
Within lineage III† NA NA NA NA NA NA
Within lineage IV‡ NA 18 NA NA 13 5
Between lineages I and II 27 22 27 19 11 6
Between lineages I and III 28 23 19 19 11 8
Between lineages I and IV NA 24 NA NA 19 9
Between lineages II and III 27 22 28 19 11 6
Between lineages II and IV NA 24 NA NA 18 10
Between lineages III and IV NA 25 NA NA 19 11

*nt, nucleotide; aa, amino acid; GPC, glycoprotein precursor; NA, not applicable. Pairwise genetic distances (uncorrected p values) were measured eliminating all positions containing alignment gaps and missing data.
†Only 1 sequence in lineage III.
‡No available L sequence in lineage IV.

Main Article

1These authors contributed equally to this article.

2Current affiliation: University of Texas Medical Branch, Galveston, Texas, USA.

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