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Volume 16, Number 7—July 2010

Dispatch

Postexposure Treatment of Marburg Virus Infection

Thomas W. GeisbertComments to Author , Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, and Heinz Feldmann
Author affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA (T.W. Geisbert, J.B. Geisbert); US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA (L.E. Hensley, J.C. Johnson); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Leung, A. Grolla); National Institutes of Health, Hamilton, Montana, USA (H. Feldmann)

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Table 1

Viral load in rhesus monkeys after Marburg virus challenge*

Animal no. Group Treatment Time of treatment after challenge, h Plasma†
PBMC
Day 6 Day 10 Day 14 Day 6 Day 10 Day 14
1 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (+) NT
2 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (+) NT (–)
3 Exp 1 VSV-Marburg 24 3.76 (–) 6.19 (+) NT (–) NT (+)
4 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
5 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
6 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
Control 1 Cont 1 VSV-Lassa 24 3.76 (–) 7.33 (+) NT (–) NT (+)
7 Exp 2 VSV-Marburg 48 0 (–) 4.20 (+) 0 (–) NT (+) NT (+) NT (–)
8 Exp 2 VSV-Marburg 48 0 (–) 7.27 (+) NT (+) NT (+)
9 Exp 2 VSV-Marburg 48 3.76 (–) 7.25 (+) NT (+) NT (+)
10 Exp 2 VSV-Marburg 48 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
11 Exp 2 VSV-Marburg 48 5.24 (+) 7.35 (+) NT (+) NT (+)
12 Exp 2 VSV-Marburg 48 3.76 (–) 6.81 (+) NT (–) NT (+)
Control 2 Cont 2 VSV-Lassa 48 4.05 (–) 7.24 (+) NT (+) NT (+)
Control 3 Cont 3 None NA 5.07 (+) 7.15 (+) NT (+) NT (+)

*PBMC, peripheral blood mononuclear cells; Exp, experimental; VSV, vesicular stomatitis virus; NT, not tested; Cont, control; (+), sample positive for Marburg virus by reverse transcription–PCR (RT-PCR); (−), sample negative for Marburg virus by RT-PCR; NA, not applicable.
†Log10 PFU of Marburg virus per milliliter of plasma.

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